Folie 1

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• GnRH and Triptorelin
• Isolation, identification and synthesis of GnRH
  originally carried out by Schally Guillemin

• Natural GnRH peptide chain of 10 amino acids

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GnRH and Triptorelin

• Replacement of the amino acid in position 6
  (glycine) by-tryptophan

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Main differences between naturally occurring
GnRH and GnRH agonists

• Higher affinity for the GnRH receptors in the
  pituitary
• Longer plasma half-life(more resistant to
  enzymatic breakdown in the blood)

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Action of a GnRH-Agonist
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The competitors