Metabolism

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Metabolism

• Glycolysis, Gluconeogenesis, Pentose Phosphate
  Pathway

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Principles

• Pathways are irreversible
• Each pathway has a FIRST COMMITTED STEP
• All pathways are regulated
• Pathways are compartmentalized (in eukaryotic
  cells)

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Thermodynamics of Phosphate Compounds

• ATP The currency of the cell

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Other High Energy Compounds

• Acyl phosphates
• Enol phosphates
• Thioesters

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Biological REDOX Reactions

• Gain/Loss of Electrons
• Change in oxidation state (change in number of
  C-O bonds
• Removal/addition of hydrogen (hydrogenation/dehydr
  ogentation)
• Reduction potential is a measure of electron
  affinity
• High (positive) E? means high electron affinity

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Glycolysis

• 2 Phases
• Preparatory Stage
• Glucose ? 2 G-3-P
• Uses 2 ATP
• Pay-off stage
• G-3-P ? pyruvate ( 2 ATP (x 2) 2 NADH)

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