Causes, Keratoconus Treatment In Ghatkopar | mumbaieyecare

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Causes, Keratoconus Treatment In Ghatkopar
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Causes of Keratoconus A family history of
keratoconus has been established in some cases.
Most researchers believe that multiple, complex
factors are required for the development of
keratoconus including both genetic and
environmental factors. With the advent of
videokeratography to assess family members,
however, pedigrees have been analysed. These
studies show corneal changes consistent with
keratoconus in some family members, which suggest
an autosomal dominant pattern of
inheritance. Keratoconus may be associated with
wide variety of systemic and ocular
conditions. Systemic associations
Atopy (a genetic predisposition to develop an
allergic reaction) Eye rubbing seen in systemic
atopy may play a role in the development of
keratoconus. Down syndrome (Trisomy 21) In Down
syndrome (Trisomy 21), frequency of acute hydrops
is higher, perhaps because of eye rubbing and/or
these patients are treated infrequently with
keratoplasty and their disease is allowed to
progress further. Ehlers-Danlos syndrome. Marfan
syndrome.
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Ocular associations
Retinitis pigmentosa. Retinopathy of
prematurity. Fuchs corneal endothelial
dystrophy. Posterior polymorphous dystrophy.
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Contributory factors such as
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Enzyme abnormalities in corneal epithelium
Enzyme abnormalities such as increased expression
of lysosomal enzymes (catalase and cathepsin) and
decreased levels of inhibitors of proteolytic
enzymes (tissue inhibitor matrix
metalloproteinases), may play a role in corneal
stromal degradation. Differentially expressed
corneal epithelium Differentially expressed
corneal epithelium between keratoconus and myopes
(as controls) in both genetic expression and
protein expression. Molecular defect Molecular
defect producing unusual absence of water channel
protein aquaporin 5 in keratoconus as compared to
normal corneal epithelium. Gelatinolytic
activity Gelatinolytic activity in stroma
has been described, which may be due to decreased
function of enzyme inhibitors. Abnormalities in
corneal collagen and its cross-linking
Abnormalities in corneal collagen and its
cross-linking may be the cause of
keratoconus. Hard contact lens wear. To schedule
an appointment with our experts for Keratoconus
Treatment in Ghatkopar, please call us at 91
8451045935, 91-8451045934 or visit our clinic at
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