The overview of Leptin replacement therapy

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THE OVERVIEW OF LEPTIN REPLACEMENT THERAPY
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Leptin is a hormone that controls obesity and
related health issues in human bodies.
Scientists, for so many years, are engaged to
discover how to use the leptin hormone to treat
obesity.
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Hundreds of renowned names are included in the
list for example, Tuncay Delibasi the famous
Turkish professor and a medical person who is
doing his best to develop the advanced structure
of leptin replacement therapy for obesity. 
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When leptin sends neurotransmitter signals to the
brain in the hypothalamus sector, it tells the
person to stop eating to maintain his/her desired
BMI (Body Mass Index). Scientists have observed
that laboratory mice have got polymorphism in
their leptin gene. Such mutations in the gene
prevent manufacturing the required leptin
protein.
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Due to the less leptin appearance, the lab mice
have developed morbidity obesity. The other
strain has the polymorphism or mutation in the
gene encoding for LEPR (leptin receptor). In such
cases, the brain or hypothalamus is not capable
of receiving leptin signals. Therefore, signal
disruption happens and it causes mutations of
polymorphism in their leptin receptors and lab
mice become obese. 
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A comparative study has shown the involvements of
lean and obese individuals as per their leptin
hormone levels. These types of comparative
studies have developed the chances of leptin
replacement to treat obesity. This is a medical
treatment that controls leptin expression levels
in obese people and helps them to control
obesity. 
LEPTIN THERAPY
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Leptin therapy is used to reverse endocrine and
metabolic alterations that are associated with
leptin deficiency. Less number of T-cells,
defective T-cells and CD4 cause leptin
deficiency. Leptin therapy can reverse these
reductions. Tuncay Delibasi has discovered in his
latest research that leptin replacement therapy
is very useful for patients who are suffering
from congenital leptin deficiency.
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Leptin also is being used to treat energy loss
such as anorexia nervosa. Scientists have found
that immune function gets changed during leptin
replacement.