Navya_Sharma

1
Stem Cell Therapy Heart or Hype?

• The stem cell therapy is constantly emerging and
  there are newer studies every day. Lets
  familiarize ourselves with it.
• An in-depth study in the future will ensure
  proper identification of molecular differences,
  that will allow a fundamental redefinition of
  diseases at the molecular and cellular levels. It
  will also enable identification of matching
  characteristics of patients to set the strategies
  for treatment.

2
What are Stem Cells?

• Stem cells are a unique type of cells which can
  cater to treating various diseases. They also
  have the ability to differentiate themselves into
  one or more types of cells.
• While treating an injury or a disease, stem cell
  undergoes cell division and gives rise to one
  daughter stem cell and one progenitor cell. A
  progenitor cell form itself into a fully
  differentiated state, before that its just an
  intermediate cell type.
• Stem cells have different types based on their
  origin such as embryonic stem cells (ESCs) or as
  adult stem cells (ASCs).

3
How is a Normal Heart Cell?

• A human heart has the tendency to grow or renew
  itself. The number of hearing cells keeps on
  increasing while the baby is still located in the
  womb only.
• Along with the increase in our age the size of
  heart cells increases which becomes a deciding
  factor in determining the growth of heart. The
  basic characteristic of a healthy heart is that
  there is a small number of changed heart cells.
• From current data, we can see that the renewal of
  heart cells is dependent on the pre-existing
  proliferation of heart cells.

4
Benefits of Cell Stem Therapy for Heart, If any -

• Despite many remarkable successes in the field of
  translational cell-based therapies for
  cardiovascular disorders, there are many
  questions remaining to be answered. The response
  or benefits of stem cells treatment depends
  largely on the interactions between the delivered
  stem cells and the cells of the host. It is a
  certain way makes cell-based therapy dependent on
  the host rather than on pharmacological therapy.
• Most clinicians have been using adult stem cells
  from the BM, from the past decade. Theyre
  largely favoured because of their autologous
  nature and ease of isolation. However, the aim of
  regenerating cardiac muscle in humans has not
  been achieved yet.

5
Benefits of Stem Cell Therapy

• With the purpose of providing individualized
  treatments, there should be more research held in
  the field of stem cell therapy.
• Certain factors influence the disease prognosis
  and thus, the clinical outcome varies, both with
  the donor stem cell function and genetic
  background of the individual host.
• The outcome of treatment would be varying from
  person to person, hence a firm understanding
  coupled with personalized health interventions
  like cell-based therapies are needed.

6
Benefits of Stem Cell Therapy

• Stem cell treatment and other cell-based
  treatments will work better if theyre looked
  with a personalized approach.
• Factors like the heterogeneity among patient
  factors and the biology of different stem cell
  types enhance the personalized approach.
• Stem cells have the capability to regenerate
  damaged myocardium. In the future, it might be
  able to fulfil the unmet clinical needs of people
  with ischemic heart disease.