ROLIMUS 10MG TABLETS| EVEROLIMUS USES & SIDE EFFECTS

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ROLIMUS 10MG TABLETS EVEROLIMUS USES SIDE
EFFECTS

• Million Health Pharmaceuticals

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DESCRIPTION

• Rolimus 10mg is a derivative of Rapamycin
  (sirolimus) and works similarly to Rapamycin as
  an mTOR (mammalian target of rapamycin)
  inhibitor. 
• It is normally used as an immunosuppressant to
  prevent rejection of organ transplants. In a
  similar fashion to other mTOR inhibitors
  Everolimus' effect is solely on the mTORC1
  protein and not on the mTORC2 protein.

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Brain carcinoma
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PRESCRIBING INFORMATION

• Rolimus 10mg tablet are mainly indicated for the
  treatment of Renal carcinoma.Rolimus 10mg
  tablet are mainly indicated for the treatment of
  Breast carcinoma.Rolimus 10mg tablet are mainly
  indicated for the treatment of Brain
  carcinoma.Rolimus 10mg is also used in various
  advanced stage cancer in stomach, intestines or
  pancreas.

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MECHANISM OF ACTION

• Everolimus is an mTOR prohibitor, joints at high
  compatibility to FK506 binding protein 12, via
  producing drug complex which inhibits the
  specific of mTOR.This inhibition decreases the
  activity of effectors downstream, that may cause
  blockage of cell progression from G1 into S
  phase, subsequently causes cell growth arrest and
  apoptosis

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ROLIMUS 10Mg
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PRODUCT DETAILS

• Brand Rolimus Ingredients Everolimus Strengt
  h 10mgManufactured Cipla Ltd Package 10
  tablets 

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PHARMACOKINETICS

• ABSORPTION
• The high plasma concentration time of Everolimus
  is 1 to 2 hours.
• METABOLISM
• The metabolism of Everolimus is occurred in
  liver, which is a substrate of CYP3A4.
• EXCRETION
• The major route of elimination 5 in urine the
  parent compound has been detected in urine or
  feces. 

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DOSAGE MANAGEMENT

• In breast cancer, renal cell cancer, pancreatic
  cancer, Neuro endocrine cancerThe prescribed
  dosage is 10mg should be taken as a single
  dose.In Brain or intracranial cancerThe
  prescribed dosage of Rolimus 10mg is 4.5mg/m2
  orally as a single dose.In pediatricThe usual
  pediatric dosage of Rolimus 10mg tablet in brain
  or intracranial tumor is 4.5mg/m2 should be taken
  orally as a single dose. Rolimus 10mg
  tablet should be administered with or without
  food.

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PRECAUTIONS

• Lymphomas
• Increased exposure of skin cancers, patient may
  protect from UV lightSerious infections
• Patients receiving Rolimus 10mg have high risk of
  acquiring various infections related to bacteria,
  virus, and fungi. Anti-microbial agents are
  preferred for the suspected patients.

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SIDE EFFECTS

• Hypersensitivity reactions Lymphomas other
  malignancy Serious infections Kidney graft
  thrombosis Hepatic artery thrombosis
  Nephrotoxicity Hyperlipemia Angioedema
  Interstitial lung disease Thrombocytopenia
  Male infertility Proteinuria New commencement
  of diabetes .

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DRUG INTERACTION

•  Rolimus 10mg interaction with strong inhibitor
  of CYP3A4, or P-gp, leads to cause decreasing the
  efflux of Everolimus and increase the plasma
  concentration of Everolimus. Combination
  of Rolimus 10mg with verapamil leads to
  increasing the plasma concentration of
  Everolimus. Combination of Rolimus 10mg with
  Atorvastatin or pravastatin causes
  rhabdomyolysis, due to increasing concentration
  of lipid lowering agents. Rolimus
  10mg combination with strong CYP3A4 inducers,
  causes increasing the exposure of Everolimus.

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CONTRAINDICATIONS

• Some anaphylactic reaction occurs, if patients
  are contraindicated to the components present in
  the ROLIMUS 10mg

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PREGNANCY

• Pregnancy category C Rolimus 10mg is needed only
  by the patients after knowing the benefits to the
  mother outweighs the risk to fetus.

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STORAGE

• Rolimus 10mg tablet should be kept at 25CKeep
  the tablet away from moisture, heat and
  lightDispense only in original container.

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MISSED DOSE

• If patient failed to take a single dose, patients
  must consult with medical practitioner and follow
  the instructions given by them. Or the missed
  dose should be avoiding and follow the regular
  dosing schedule.

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OVERDOSAGE

• The over dosage of Everolimus is rarely occur, in
  case of over dosage patient must be provide with
  supportive measures. The acute toxicity of
  Everolimus over dosage should be monitored.

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CONTACT US

• PHONE NO91-9940472902
• EMAILmillionhealthpharmaceuticals_at_gmail.com
• WEBSITE URLhttps//millionpharma.com/rolimus-10-m
  g.php