DNA repair systems

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DNA Repair Systems
R. C. Gupta Professor and Head Department of
Biochemistry National Institute of Medical
Sciences Jaipur, India
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E M B - R C G
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E M B - R C G
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E M B - R C G
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E M B - R C G
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E M B - R C G
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E M B - R C G
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Mismatch repair system
E M B - R C G
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E M B - R C G
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E M B - R C G
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E M B - R C G
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In E.coli, the system is made up of three
proteins - MutS, MutL and MutH
MutS scans the new strand from one GATC sequence
to another
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If it finds a mispaired base, it binds to it
Then, MutL binds to MutS
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E M B - R C G
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E M B - R C G
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Base excision repair system
E M B - R C G
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E M B - R C G
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Nucleotide excision repair system
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E M B - R C G
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E M B - R C G
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Thymine dimer distorts the helix
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E M B - R C G
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E M B - R C G
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E M B - R C G
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E M B - R C G
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E M B - R C G
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E M B - R C G
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E M B - R C G
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E M B - R C G
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Double strand break repair system
E M B - R C G
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E M B - R C G
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E M B - R C G
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Homologous recombination
E M B - R C G
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E M B - R C G
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E M B - R C G
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Non-homologous end joining
E M B - R C G
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E M B - R C G
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Thank you