Nigerian Scientists Confirm The power Of Jobelyn

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Nigerian Scientists Confirm The power Of Jobelyn
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Scientists from Neuropharmacology Unit,
Department of Pharmacology and Therapeutics,
College of Medicine, University of Ibadan,
Nigeria led by Solomon Mukoro P hd. in a recent
animal model in vivo study postulates that
Jobelyn has the potential to treat Rheumatoid
Arthritis in human.
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In a recent article published in the journal
"Biomedicine Pharmacotherapy"
https//doi.org/10.1016/j.biopha.2017.12.098 it
was reported that Rheumatoid arthritis (RA) is a
chronic inflammatory disease that affects the
physical and psychosocial well being of the
patients and a major cause of work disability.
Current drugs for its treatment only provide
palliative effect, as cure for the disease still
remains elusive. Jobelyn (JB), a potent
anti-oxidant and anti-inflammatory dietary
supplement obtained from Sorghum bicolor, has
been claimed to relieve arthritic pain. Thus,
this study was designed to evaluate its effect on
inflammatory and biochemical changes as well as
neurobehavioural deficits associated with
complete Freund-adjuvant (CFA)-induced arthritis
in mice.
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The effect of JB (50, 100 and200 mg/kg) on
inflammatory oedema, neurobehavioural deficits,
levels of biomarkers of oxidative stress and
inflammatory cytokines (tumor necrosis
factor-alpha and interleukin-6) induced by 0.1 mL
of CFA (10 mg/mL)was evaluated in male Swiss
mice. Oral administration of JB (100 and 200
mg/kg) reduced inflammatory paw volume and
reversed sensori motor deficits induced by CFA.
JB also reduced pain episodes, anxiety and
depressive-like symptoms in CFA-mice.
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The increased level of oxidative stress in the
joint and brain tissues of CFA mice was reduced
by JB. It also decreased tumor necrosis
factor-alpha and interleukin-6 levels induced by
CFA inthe joint tissue of mice. These findings
suggest that Jobelyn attenuates inflammatory
responses induced by CFA in mice via inhibition
of oxidative stress and release of inflammatory
cytokines. The ability of JB to attenuate
CFA-induced nociception, sensori motor deficits
and depressive-like symptom suggests it might
improve the quality of life of patients with
arthritic conditions
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Results JB (50200 mg/kg) given orally produced
a significant inhibition of acute inflammation
induced by carrageenan in rats. It reduced the
volume and number of leukocytes in inflammatory
fluid in the granuloma air pouch model of chronic
inflammation. It further decreased the levels of
MDA in the fluid suggesting antioxidant property.
JB elevated the concentrations of GSH in
inflammatory exudates indicating free radical
scavenging activity. It also significantly
inhibited RBC lysis caused by hypotonic medium,
suggesting membrane-stabilizing property.
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