Toxicity Testing Labs Services

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Typesof Toxicity Studies
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What is a toxicity or toxicology study?
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Toxicology study is the study of the toxic
effects produced by a drug or a chemical on
experimental animals
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It is important for the development of new
drugs or extension of the existing drugs for
human use
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What are the types of toxicity studies?

• Single dose/Acute toxicity study
• Repeated dose/ Chronic toxicity study
• Local toxicity study
• Hypersensitivity toxicity study
• Genotoxicity study
• Carcinogenicity/Oncogenicity study

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Acute Toxicity Study

• Is carried out on two different animal species
  (rodent and non-rodent)
• The investigational drug is administered as a
  single dose or in multiple varying doses
• The effects are observed for 14 days
• Morphological, pathological,
• biochemical, and histological
• changes in live and dead animals
• are recorded

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Chronic Toxicity Study

• Is carried out on one rodent and one non-rodent
  animal species
• The investigational drug is administered in a
  dose based on dose-relationship studies for 90
  days
• The drug is administered orally
• Gross and microscopic pathological
• changes, changes in animal
• physiology and behavior are recorded

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Local Toxicity Study

• According to the anatomical region studied for
  the toxic effects
• Dermal toxicity
• Dermal photo-toxicity
• Vaginal toxicity
• Rectal tolerance
• Ocular toxicity
• Respiratory toxicity

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Dermal Toxicity

• Carried out on Rats and Rabbit
• Local signs on the skin like
• oedema and erythema are recorded
• Histological examination of skin
• tissue is done

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Dermal Photo-toxicity

• Carried out on guinea pig
• Local skin changes are recorded

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Vaginal Toxicity

• Carried out on rabbit or dog
• Histopathological changes in the
• vaginal wall are recorded

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Rectal Tolerance

• Carried out on rabbit or dog
• Histological changes in rectal
• mucosa, any blood or
• mucus discharge recorded

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Ocular Toxicity

• Carried out on Albino rabbit
• Histological changes in eye, changes
• in iris, cornea, and aqueous
• humor recorded

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Respiratory Toxicity

• Carried out on two species, one rodent and other
  non-rodent
• Respiratory rate observed
• Histological changes in respiratory
• passage and lung tissue recorded

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Hypersensitivity Toxicity

• Carried out on Guinea pig
• Maximum non-irritant or minimum irritant dose of
  the drug determined
• Erythema, oedema, and local lymph
• nodes evaluated

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Genotoxicity Study

• Carried out in vitro as well as in vivo
• Gene mutation, chromosomal damage, and early
  tumorigenic effects are recorded

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Carcinogenecity Study

• Performed on life-time bioassays
• Investigational drug administered for more than 6
  months
• Carcinogenic potential of the drug
• noted from its chemical structure

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Where are animal toxicity testing performed?
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In hi-tech animal toxicity testing labs
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To find one

• Email ID project_at_cognibrain.com
• Phone [phone]
• Visit us https//www.cognibrain.com/
• Connect with us