Can Green Tea Improve the Down Syndrome Symptoms?

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Can Green Tea Improve the Down Syndrome Symptoms?
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• Interesting revelation from Phase II clinical
  trial suggests that Green tea can improve
  the intellectual capacities of the Down syndrome
  patients.

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• Scientists from Centre for Genomic Regulation
  (CRG) made an interesting revelation about the
  link between one of the compounds present in the
  healthy morning refreshment- Green tea and
  improvement in the intellectual capacities of a
  person with Down syndrome.

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• Epigallocatechin gallate (EGCG) is a catechin
  compound which is present in excess in tea.
  DYRK1A (Dual-Specificity Tyrosine-(Y)-Phosphorylat
  ion Regulated Kinase 1A) is an enzyme encoded by
  DYRK1A gene in humans which are considered as a
  gene responsible for the learning defects
  associated with

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• Down syndrome and also affects the brains
  ability to change in a normal way
  (neuroplasticity).  In the clinical trials, EGCG
  has been shown to improve the cognitive functions
  of the patients with Down syndrome.

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• The Phase II study was led by Rafael de la Torre
  and team on 84 patients of age group 16-34 years
  at the IMIM-Hospital del Mar Medical Research
  Institute. The patients were given EGCG (9 mg/kg
  per day) or placebo along with the cognitive
  training for 12 months and later followed up for
  6 months after treatment was discontinued.

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• Patients treated with EGCG significantly scored
  higher in visual recognition memory, inhibitory
  control and adaptive behaviour. EGCG is known for
  the inhibition of excess DYRK1A gene in mice in
  earlier studies and now it was also shown
  effective in humans with Down syndrome. The study
  was published in The Lancet Neurology.

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• WHO has reported that 1 out of 1000 persons is
  affected with Down syndrome globally. Down
  syndrome is a genetic disorder caused due to the
  presence of three copies of chromosome 21 which
  leads to the overexpression of the genes present
  on this chromosome. DYRK1A is one of the genes
  present in chromosome 21.

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• The researchers of IMIM and CRG demonstrated that
  the compound EGCG functions in inhibiting the
  excess function of DYRK1A which leads to the
  improvement of the cognitive functions of the
  brain when given along with the cognitive
  training.

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• To reinforce the effect of EGCG and cognitive
  training on the cognitive functions of the
  patients with Down syndrome, Phase III trial will
  be performed on a larger group of Down syndrome
  patients.

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