Is Prevention from Zika Virus Lies Inside Human Body

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Is Prevention from Zika Virus Lies Inside Human
Body?
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• Researchers discovered that an endogenous protein
  can prevent the replication of Zika virus.Amidst
  all the research and development going on to
  develop medications and vaccines to combat
  against dreadful Zika virus pandemic,

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• A team of researchers from University of
  Massachusetts Medical School (UMMS) discovered
  interferon-induced transmembrane protein
  (IFITM3) a human protein present inside our own
  bodies can prevent us from getting infected by
  Zika virus by blocking its replication.

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• IFITM is a human protein encoded by IFITM genes.
  These proteins express it in different tissues
  and cells and take part in germ cell maturation
  and development and immune response signalling.

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• When the UMMS researchers charged the Zika virus
  infected cells with IFITM3, their replication got
  drastically reduced. It indicated that IFITM3 can
  inhibit the initial stages of Zika virus
  replication and also prevent the death of our
  cells by Zika virus.

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• The Brass and team noticed that the level of
  IFITM3 in the cell membrane is essential for the
  defense of the body against the Zika infection.
  In the case of low level of IFITM3, the Zika
  virus can easily penetrate inside the cell and
  when the IFITM3 is present in sufficient amount
  in the membrane it prevents the virus from
  reaching inside and stops the infection.

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• The exact mechanism of IFITM mediated Zika virus
  restriction is not known but the earlier findings
  related to the anti-viral actions of IFITMs
  against the other related flaviviruses like
  dengue virus and west Nile virus supported the
  efficiency of IFITMs as a potential inhibitor of
  various life threatening emerging viruses like
  dengue and Ebola.

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• Both anti-viral proteins, IFITM1 and IFITM3 can
  inhibit Zika virus infection but IFITM3 is the
  most efficient one. The cytopathic effect which
  causes structural changes in the cells due to
  viral attack can also be avoided by the
  expression of IFITM2 and IFITM3. The complete
  study is published in Cell Reports.

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• The outbreak of Zika virus epidemic in the US
  occurred in 2015. Till now, no treatment has been
  developed for Zika virus infection. Many pieces
  of evidence of microcephaly (severe brain
  deformation in infants) also came to light caused
  due to Zika virus infection in the pregnant women.

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• This research indicated that the tool for the
  eradication of Zika virus is present inside the
  human body who became the victim of this virus in
  ignorance. Now, the further enhancement of the
  mechanism of IFITM against the emerging dreadful
  viruses can help in the eradication of the risk
  to human health posed by these viruses.

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