Root Deep Absolute Advance III - Clinical Backbone

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Clinical Backbone
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10 Actions against all 5 concerns of hair fall
and decreased hair density / growth on all 3
parts of hair.
The Everything (Hair) Therapy
Fall Reduction Root Energizing Blockage Clearing
4 Nourishing oils
Anti Scalp Ageing Dandruff Removal
10 Phytonutrient extracts
Shaft Strengthening Volumizing Instant
Shine Smoothening Frizz Control
17 Keratin resembling plant amino acids
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Concern Active Ingredient Efficacy data Formulation details
Fall Reduction Pisum sativum sprout extract Increase of growth coefficient (A/T) by 78 in 12 weeks with improvement in hair and scalp quality by more than 80 Root Deep Hydroil
Fall Reduction Ocimum basilicum hairy root culture extract 23 increase in dermal papilla cells after 1 month 30.7 decrease in hair fall in 2 months Root Deep Hydroil
Fall Reduction Pterocarpus marsupium bark extract Reduction of hair fall in male volunteers with androgenic alopecia Frontal zone 33 in 4 months Occipital zone 46 in 4 months Root Deep Hydroil Root Deep Shampoo
Root Energizing Plant extracts with Hexapeptides-11 Around 20 decrease in hair removal due to enlargement of hair bulb after 5 applications Elementi Puro Root Recharge synergy
Root Energizing Vanillyl Butyl Ether 66.4 increase in scalp microcirculation(10 Minutes after application) Increase in IGF-1 production that will lead to increase in Anagen hair density Elementi Puro Root Recharge synergy
Blockage Clearing Ocimum basilicum hairy root culture extract Upto 80 reduction in sebum as compared to 70 with Finasteride after 72 hours Root Deep Hydroil
Blockage Clearing Zinc PCA 65 of Anti 5-a reductase activity compared to positive control in 28 days Elementi Puro Root Recharge synergy
Anti Scalp Aging Pterocarpus marsupium bark extract 54 of reduction in glycation after 15 days 78 of free radical inhibition in spot laboratory studies (in tubo) Root Deep Hydroil Root Deep Shampoo
Dandruff Removal Piper nigrum fruit extract and Inga alba bark extract Effective against dandruff-causing bacterial strain at low MIC Around 40 reduction in dandruff after 42 days Around 50 reduction in sebum 42 days Root Deep Hydroil Root Deep Shampoo Root Deep Intenso Fluid
Shaft Strengthening Hydrolyzed Pea Protein 4.0 increase in tensile strength of Hair after each application 4.3 increase in Cross section area of Hair after each application 5.71 increase in Hair moisture after each application Root Deep Shampoo Root Deep Intenso Fluid
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Proven Hair Fall reduction
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Pisum sativum sprout extract

• Study design I
• Study period of 12 weeks used twice daily
• 20 volunteers of age 21-37
• 17 females with hair in telogen phase gt 15
• 3 males with hair in telogen phase gt 20

Incorporated in Root Deep Hydroil
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Effect on hair fall
Results

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Reduction of Hair fall
Results

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Effect on A/T ratio
Results

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Response from volunteers
Results

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Pisum sativum sprout extract
Study design II

• Study period of 14 days used twice daily
• 10 volunteers of age 46-60
• 4 females
• 6 males

Incorporated in Root Deep Hydroil
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Effect on the expression of dermal papilla
signaling molecules
Results

• Noggin A protein that shortens the telogen
  phase
• FGF-7 - Fibroblast growth factor 7 that
  initiates new anagen phase

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Ocimum basilicum hairy root culture extract

Biotechnologically derived, holy plant extract
with Anti 5-alpha reductase activity. Provides
nourishment to starving hair roots promotes
fuller, denser hair. 5a reductase is the key
target enzyme in the inhibition of hair loss.
Basil root Culture extract inhibit 5a reductase.
Testosterone will not convert into
dihydrotestosterone (DHT) in absence of 5a
reductase.   The results showed a clear
concentration dependent inhibition of 5a
reductase. Consequently, Basil root Culture
extract was able to reduce hair loss in people
with androgenic alopecia.
Incorporated in Root Deep Hydroil
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Increased proliferation of Dermal papilla cells
Results

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Ocimum basilicum hairy root culture extract

Study design

• Study period of 2 months used once daily
• 21 volunteers of age 25-67 with daily hair loss gt
  100 strains
• 19 females
• 2 males

Incorporated in Root Deep Hydroil
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Results

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Pterocarpus marsupium bark extract

Study design

• Study period of 6 months used once daily against
  placebo
• 40 male volunteers of with androgenic alopecia

Incorporated in Root Deep Hydroil Root Deep
Shampoo
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Results

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Proven Root Energizing
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Plant extracts with Hexapeptides-11

• Plant extracts like sugar cane extract, Lemon
  fruit extract, Apple fruit extract, green tea
  leaf extract along with Hexapetides-11 restores
  hair and scalp vitality at cellular level and
  energizing hair bulb

Incorporated in Elementi Puro Root Recharge
Synergy
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Plant extracts with Hexapeptides-11

Study design

• Study period of 5 days used once daily
• 15 volunteers of age 30-60 with hair length of
  not less than 12 inches

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Results

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Results

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Vanillyl Butyl Ether

• Enhances microcirculation of blood flow with
  lesser irritation and warming sensation

Incorporated in Elementi Puro Root Recharge
Synergy
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Increase in Blood flow
Results

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Effect on the production of IGF-1
Results

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Proven Blockage Clearing
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Ocimum basilicum hairy root culture extract

Biotechnologically derived, holy plant extract
with Anti 5-alpha reductase activity. Provides
nourishment to starving hair roots promotes
fuller, denser hair. 5a reductase is the key
target enzyme in the inhibition of hair loss.
Basil root Culture extract inhibit 5a reductase.
Testosterone will not convert into
dihydrotestosterone (DHT) in absence of 5a
reductase.   The results showed a clear
concentration dependent inhibition of 5a
reductase. Consequently, Basil root Culture
extract was able to reduce hair loss in people
with androgenic alopecia.
Incorporated in Root Deep Hydroil
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Results

Inhibition of 5a reductase
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Zinc PCA

• Zinc salt of pyrrolidone carboxylic acid, a
  double acting complex that optimally allies the
  beneficial effects of zinc and L-PCA,
  physiological components of the organism.

Incorporated in Elementi Puro Root Recharge
Synergy
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Zinc PCA

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Zinc PCA

Study design

• Inhibition of 5a reductase
• Pre-incubation of human Dermal fibroblasts in
  presence of Zinc PCA / Zinc chloride and Addition
  of radioactive (titrated) Testosterone and
  incubation for 24 hours / preparation of
  cellHomogenates by sonication and Radioactivity
  measurement
• Anti 5-alpha reductase activity of Zinc PCA
  (65) much higher than Zinc chloride (45)
• Intrinsic activity of Zinc PCA greater than
  equimolar quantity of Zinc chloride.

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Results

Inhibition of 5a reductase
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Zinc PCA

Study design

• Seboregulatory activity
• Sebometric study on 2 groups of 16 volunteers
  after 28 daily application on the half forehead
  with a cream containing 1 Zinc PCA vs Placebo
  and non-treated zone

Results
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Zinc PCA

Study design

• Antimicrobial activity
• Minimum Inhibitory Concentration of Zinc PCA was
  identified and optimized for various bacterial
  and fungal strains.

Results
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Proven Anti scalp Aging
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Pterocarpus marsupium bark extract

Study design

• Anti glycation activity
• Against aminoguanidine as positive control

Incorporated in Root Deep Hydroil Root Deep
Shampoo
Results
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Results

• Anti free radical activity

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Pterocarpus marsupium bark extract

Anti-inflammatory effect Study design I

• Test on Keratinocytes
• On the model of UVB induced inflammation against
  positive control of Aspirin
• Incubation period of 72 hours

Results
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Pterocarpus marsupium bark extract

Anti-inflammatory effect Study design II

• Test on Polymorphonuclear neutrophilic
  granulocytes (PMN)
• On the model of UVB induced inflammation against
  positive control of Minocyclin
• Incubation period of 24 hours

Results
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Proven Dandruff Removal
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Piper nigrum fruit extract and Inga alba bark
extract

Anti microbial activity Study design

• Study period of 6 months used once daily against
  placebo
• Against Bacterial strains Malassezia globosa and
  Malassezia furfur, responsible for dandruff,
  inflammation and irritation
• Incubation period of 48 hours

Incorporated in Root Deep Hydroil Root Deep
Shampoo Root Deep Intenso Fluid
Results
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Piper nigrum fruit extract and Inga alba bark
extract

Anti inflammatory activity Study design

• On human keratinocytes on the model of UVB
  induced inflammation against positive control of
  Aspirin
• Incubation period of 48 hours

Results
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Piper nigrum fruit extract and Inga alba bark
extract

Improvement of Scalp properties Study design

• To evaluate the scalp conditions (dandruff,
  sebum) against a shampoo with 1 zinc pyrithione,
  after 4 weeks of treatment and 2 weeks of
  remanence period

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Results

Reduction in Dandruff
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Results

Reduction in Sebum
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Results

Response of Volunteers
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Proven Shaft strengthening
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Hydrolyzed Pea Protein

• 17 keratin resembling plant amino acids
• Improves hair strength lost by damages
• Restores hair moisture and prevents dry hair
• Smoothens hair surface

Incorporated in Root Deep Shampoo Root Deep
Intenso Fluid
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Results

Tensile strength measurement
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Results

Cross-section measurement
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Results

Hair moisture measurement
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The Difference
When it comes to cleaning, sensitive skin/hair
possesses the common phenomena of over
sensitivity towards traditional cleansers. Let's
clean it with sulphate free, biodegradable
cleansers. It's your body it's your world.
Stand By The Environment.
Natural is the most over utilized but perhaps the
least specified term in personal care creations.
Whenever you make a choice of using natural
products, the question is "how much nature does
it actually hold"? Subtracting the water part,
nature score indicates the exact percentage of
natural ingredients in your selected Brillare
science product. So the next time when you read
our score, count your nature proximity be
assured of our constant endeavor to keep you as
close as possible-to nature.
Personal care cosmetics are formulated with dual
purpose of action. One is for the concern
specific efficacy and other is for the wellness
feel it imparts on human body and soul. Active
score is brillare research laboratory's conscious
effort to formulate the personal care cosmetics
which carries higher percentage of concern
specific active ingredients. These active
ingredients are carefully combined with
organoleptic advancements in cosmetic base. It
brings better efficacy, enhanced nourishment and
greater cosmetic wellness.
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The Difference
Patented Anti hair fall and Hair regrowth
promoting Nature quantified formulations India
first World first Patent pending for deep
penetrating micro-emulsion techniques of Hydroil
Root Recharge Synergy
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