Phases of

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Phases of Lymphocyte Activation
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T Lymphocyte Subsets and their Effector Functions

• Lecture 9

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Humoral and Cell-Mediated Immunity
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Listeria Control
No
Serum
Listeria Challenge
T Cells
Listeria Recovered Mice
Yes
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Cell-Mediated Immunity

• Protects against Intracellular pathogens and
  Cancer
• Responsible for graft rejection.

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T Cell-Mediated Defense Against Intracellular
Microbes
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Cell-Mediated Immunity

• CD4 T Cells
• CD8 T Cells
• NK Cells

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CD4 T Cells
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• The Effector Function of CD4 T Cells is
  Determined by the array of Effector Molecules
  they Produce-Cytokines

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Cytokines- Intercellular Messengers In
Immune System
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Cytokines
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Properties Of Cytokines
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Subsets of CD4 Effector Cells
TH0 Cell
TH1 Cell
TH2 Cell
IFNg, IL-2, TNFa, Lymphotoxin
IL-4, IL-5, IL-6, IL-10
B Cell Activation
Macrophage Activation
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IFNg
Effector Functions of TH1 CD4 T
Cells (Cell-Mediated Immunity)
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Effector Functions of TH2 CD4 T Cells (Humoral
Immunity)
IL-4
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Differentiation of TH1 and TH2 Subsets of
Effector CD4 T Cells
IL-12
IL-4
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Cross-Regulation
TH0 Cell
IFNg suppresses Development of TH2 Cells
IFNg, IL-2, TNFa, Lymphotoxin
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Cross-Regulation
IL-10 suppresses TH1 Response
IFNg suppresses TH2 Response
IL-4 IL-5 IL-6 IL-10
IFNg, IL-2, TNF?, Lymphotoxin
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LEISHMANIA (PROTOZOAN PARASITE)
BALB/c Mice
C57BL/6 Mice
Uncontrolled Leishmania Replication
Clearance of Leishmania
Live Happily
Fatality
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LEISHMANIA (PROTOZOAN PARASITE)
C57BL/6 Mice
BALB/c Mice
TH1 CD4 Response
TH2 CD4 Response
Activate Infected Macrophages
Unable to Activate Macrophages (Infected)
Clearance of Leishmania
Live Happily
No Inhibition of Leishmanial growth
Fatality
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LEISHMANIA (PROTOZOAN PARASITE)
Block IL-4 by Injecting anti-IL-4 Antibody (First
days of Infection)
BALB/c Mice
TH1 CD4 Response
Activate Infected Macrophages
Clearance of Leishmania
Live Happily
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• TH17 Effector Cells

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• TH17 Effector Cells