CellCell Interactions

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5 March 2007
MBI Journal Club on Models of Cell-Fate Regulation
Cell-Cell Interactions Inflammation
Part Six
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http//www.biologymad.com/Immunology/inflammation.
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A CONCEPTUAL MODEL
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P
0
0

N
0


D
0


CA



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assume M at steady state
growth
Logistic growth of pathogen
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activated phagocytes
pathogens
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activated phagocytes
pathogens
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activated phagocytes
pathogens
N/(1(CA/c8)2)
R1/(1(CA/c8)2)
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Figure 2(a)
s
Septic death
u
u
s
health
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Figure 2(b)
SN
Hopf
OSCILLATIONS (un-biological not observed)
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Figure 2(c)
Hopf
SN
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Figure 2(b)
Figure 2(c)
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N/(1(CA/c8)2)
R2/(1(CA/c8)2)
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ASEPTIC DEATH
HEALTH
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FIGURE 4(a)
SEPTIC DEATH
ASEPTIC DEATH
HEALTH
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FIGURE 4(b)
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ASEPTIC DEATH
SEPTIC DEATH
HEALTH
P
0
0

N
0


D
0


CA



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STATIC VERSUS DYNAMIC CA
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CA AND PATHOGEN INFECTION BETWEEN HEALTH AND
DEATH
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SIMULATING THERAPEUTIC INTERVENTION WITH CA
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SIMULATING THERAPEUTIC INTERVENTION WITH CA