The First Brain Imaging Experiment

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The First Brain Imaging Experiment
and probably the cheapest one too!
Angelo Mosso Italian physiologist (1846-1910)
In Mossos experiments the subject to be
observed lay on a delicately balanced table which
could tip downward either at the head or at the
foot if the weight of either end were increased.
The moment emotional or intellectual activity
began in the subject, down went the balance at
the head-end, in consequence of the
redistribution of blood in his system. --
William James, Principles of Psychology (1890)
From fMRI for Dummys
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Exact
Estimate
41 37
.
41 36
.
1423
1423
300 msec
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Odor evoked activity at 800msec
Rapid Transition
Slow Transition
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Brain Imaging Anatomy
CAT
PET
Photography
MRI
Source modified from Posner Raichle, Images of
Mind
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Slice Terminology
From fMRI for Dummys
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MRI vs. fMRI
Functional MRI (fMRI) studies brain function.
MRI studies brain anatomy.
From fMRI for Dummys
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fMRI Activation
Flickering Checkerboard OFF (60 s) - ON (60 s)
-OFF (60 s) - ON (60 s) - OFF (60 s)
Brain Activity
Source Kwong et al., 1992
From fMRI for Dummys
Time ?
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EEG
ERP
Spatial precision
PET
fMRI
perfect
Temporal precision
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So how do brains really work?
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Hydrolic Clock Dynamo Telephone Analog
Computer Digital Computer Hologram Digital
Computer
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