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Christopher Hentschel, Ph.DChief Executive
OfficerMedicines for Malaria Venture
Fighting Malaria Through Effective
Partnerships
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What is Malaria RD

• Create new and improved tools such as
  easier-to-use diagnostics, longer-lasting ITNs,
  more effective insecticides, new and better
  antimalarial drugs, vaccines and new vector
  control methods
• Maximize the effectiveness of existing malaria
  control tools, i.e., implementation research to
  improve ITN and insecticide use, diagnosis, and
  treatment
• Build capacity in endemic countries to design,
  conduct, and exploit the research necessary to
  solve the malaria problem

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The Innovation Gap

• Factors that impede malaria RD
• Lack of a viable commercial market
• Costs
• Poor infrastructure
• Scientific hurdles
• The Result
• Old, cheap and accessible drugs are largely
  useless in endemic regions due to drug resistance
• Little progress in vaccine development
• Although malaria is preventable and curable,
• Over 3,000 children die of malaria every day.

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Quantum Leap in 5 years

• Through Public-Private Partnerships focused on
  developing new products, improving the use of
  existing tools, and building capacity to deliver
  health care,
• the gap is narrowing.

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Quantum Leap in 5 yearsProduct Development PPPs

• MMV has the largest-ever portfolio of
  antimalarial drugs over 20 projects
• 6 drug candidates are in late-stage clinical
  studies
• Delivery of at least 1 new drug before 2010
• MVI proved that a vaccine against a parasitic
  disease is feasible
• Largest study in children showed significant
  efficacy in clinical malaria
• A partially effective vaccine is foreseen by 2010

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MMVs mission is

• DISCOVER
• DEVELOP
• DELIVER

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Its drugs should be Public Goods

• APPROPRIATE
• AFFORDABLE
• ACCESSIBLE

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Public-Private PartnershipKey to Delivering
Health Impact

• Public Input
• Academia Public Research Institutes
• ideas, expertise, opportunities, contacts,
  network
• Governments FUNDING
• Private Input
• Pharmaceutical Biotech Industry
• facilities, know-how, technology
• Philanthropic Foundations FUNDING
• PPPs Portfolio Management
• Reduces Risks
• Creates Synergies
• Optimizes Use of Resources

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Sun never sets on MMVs global RD efforts
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 Malaria RD PPPs Aim

• Attributable Health Impact saving
  malarias main victims is the bottom line for
  which we are held accountable

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It is very hard to tell a mother that her child
died because the drugs we can afford in our
public health systems often dont work any more
we can only imagine the difference partnerships
like MMV might have made if they had started
their work 20 years ago " President Joachim
Chissano June 1st 2004 51,000 children die of
malaria each year in Mozambique
Thank You