ITC Tobacco Product Repository

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ITC Tobacco Product Repository

• Gary A. Giovino, PhD, MS
• Roswell Park Cancer Institute
• Buffalo, New York (USA)

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Overview

• Importance of tobacco product surveillance
• Overview of International Tobacco Product
  Repository
• Testing methods
• Policies evaluated
• Preview of Product Testing and Monitoring
  Watson/OConnor Workshop

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Importance of Tobacco Product Surveillance

• Thousands of constituents in tobacco and tobacco
  smoke
• Systematic monitoring has been limited
• to tar, nicotine, and CO
• using a machine protocol that does not reflect
  human smoking patterns
• in developed countries
• Smokeless tobacco constituents not monitored
• Products change frequently
• public health impact unknown

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Marlboro Ultra Comparisons
Marlboro Ultra Light N. Dakota
Marlboro Ultra Smooth Salt Lake City
Marlboro Ultra Smooth Atlanta
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International Tobacco Product Repository

• Begun in 2003
• Cohorts of leading cigarette brands in 10
  countries (to date)
• Housed at the Roswell Park Cancer Institute
  Buffalo, New York (USA)
• Some packs are analyzed others kept for archival
  purposes

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Disposition of Cigarette Packs Entered into the
International Tobacco Product Repository as of
June 30, 2006
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Zhongnanhai sold in Beijing (not shown) has 3 mg
tar
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International Tobacco Product Repository
Super Sized Carcinogens Countries using American
blended cigarettes (US and Thailand) had
significantly higher TSNA levels than countries
using Virginia blended tobacco (Australia,
Canada, and United Kingdom) that is attributed to
higher TSNA levels found in blended varieties
that have burley tobacco
NNN levels in mainstream smoke under intense
smoking conditions
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Got smokes??
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Filter Ventilation and Physical Parameter Testing
of 99 Cigarette Varieties from Seven Chinese
Cities
Examples of Chinese cigarette pack designs

• Ventilation, rod length, and filter length
  significantly related to ISO tar yield

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Full Battery of Tests

• Design features and smoke chemistries
• DESIGN Weight, length, diameter, blend, paper
  porosity, filter type, filter weight, filter
  ventilation, pressure drop
• SMOKE CHEMISTRIES tar, nicotine, carbon
  monoxide, free nicotine, tobacco specific
  nitrosamines, polycyclic aromatic hydrocarbons
• three testing regimens possible
• Standard ISO
• Massachusetts
• Canadian (ISO Intense)

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Analysis of the Tobacco - Health Effect Process
Serum
Cigarette Tobacco
Mainstream Smoke
Blood
Cigarette Filters
Adducts
Sidestream Smoke
Urine
Cigarette Paper
Saliva
Smokeless Tobacco
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Product-related policies

• EU performance standards (2004-2007)
• 10 mg tar
• 1 mg nicotine
• 10 ppm CO
• Canadian (2005) and New York State (2004) low
  ignition propensity law
• Lower levels of TSNAs in tobacco leaf announced
  by US and Canadian cigarette manufacturers
• Regulations to prohibit light and mild labels
• FCTC

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European Commission, 200410-1-10 Policy

• Questions
• Did the companies comply with the law?
• Were the cigarettes less toxic?
• Methods
• Compared yields and design features of 10
  cigarette brands sold in the United Kingdom (UK)
  before (1999) and after (2005) the EC standard
  was implemented.

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EU 10/1/10 Policy
Before
After
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O'Connor RJ, et al, How did UK cigarette
makers reduce tar to 10mg or less? BMJ
2006332302.
479 increase in filter ventilation
Manufacturers complied with the ECs mandated
yield reduction by increasing filter ventilation
levels on cigarettesa design feature that
promotes compensatory smoking.
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People dont smoke like machines
Location of Filter vent holes
Finger or lip blockage increases mainstream smoke
deliveries(1). Air dilution may result in larger
or more frequent puffs(2) increasing delivery(3).
Air dilution through filter vent holes reduces
machine smoked mainstream deliveries.

• Kozlowski LT, Rickert WS, Pope MA, Robinson JC,
  Frecker RC (1982) British Journal of Addiction
  77, 159-165.
• Kozlowski LT, OConnor RJ (2002), Tobacco
  Control, 11, i40-i50.
• 3. Kozlowski LT, Sweeney CT, Pillitteri, JL
  (1996) Experimental and Clinical
  Psychoparmacology, 4, 404-408.

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Effect of vent blockage on machine smoked
deliveries of an ultra-light cigarette (80
filter ventilation)
Nicotine and tar levels increase 10x as filter
vent holes are blocked.
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Product Testing and Monitoring Workshop (Cliff
Watson Rich OConnor)

• The importance of product surveillance to the
  Framework Convention on Tobacco Control
• Equipment and methods for characterizing product
  differences
• How to become involved in TobLabNet and/or the
  International Tobacco Product Repository Project

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Ways to Get Involved in Product Monitoring and
Research

• We are looking to expand by 10-12 countries this
  year
• If you are interested in knowing more about the
  cigarettes available in your country, we can
  assess design features and arrange for ISO smoke
  chemistry testing at an independent lab
• Grants of up to 3500 available to facilitate
  purchases and testing
• See Dr. OConnor or Craig Steger for
• application information

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International Tobacco Products Repository

• What we do for you
• Provide packaging materials and pre-labeled
  specimen bags to make things easy.
• Provide suggestions to help identify leading
  brands in your country.
• Provide unique information about brands in your
  country and comparisons to other countries
• What you do for us
• Identify leading brands in your country
• Purchase 18 packs of each brand variety in 3
  distinct locations within each country
• Provide additional samples for comparison among
  countries
• Add to the overall value of the repository