Molecular Genetics 500

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Molecular Genetics 500 Winter 2003 M W F 12
120 PM
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Molecular Genetics 500 Winter M W F 12-120
PM Instructor Dr. Roy Tassava Bio. Sci. Rm.
282 Ph. 292-0810 e-mail tassava.1_at_osu.edu
Office hours M W 12-1pm The GTAs will hold
a help session once a week (time and place to be
determined). We expect that the majority of your
questions can be answered during these sessions.
In addition to the office hours listed above, you
may contact Dr. Rudge or one of the GTAs via
phone or e-mail to arrange an appointment at
another time if you are unable to meet during the
scheduled office hours. THIS COURSE MOVES
RAPIDLY! IT IS IMPORTANT THAT YOU DO NOT ALLOW
YOURSELF TO GET BEHIND!! Textbook Concepts of
Genetics. William S. Klug Michael R. Cummins.
6th Edition. 2000. Prentice Hall. Course Web
Site
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Examinations There will be two midterm exams and
a final exam. Each exam will be worth 33 of the
final grade (100 points each, for a total of 300
points for the course). Each exam will primarily
cover the material since the previous exam.
However, the course material builds on itself, so
a strong performance on one exam helps to insure
a strong performance on the next. Midterm exams
will only be given at the scheduled times.
Make-up midterm exams will only be given if there
is a LEGITIMATE PROVEN excuse. The make-up exam
will be re-designed and the format will be at the
discretion of the instructor. The final exam
must be taken to receive a grade in the course.
University regulations will be adhered to in
dealing with absenteeism at final exams.
Graduating seniors will be given an "early" final
exam (time and place to be determined). Format
of exams will be multiple choice, short answer,
and problem solving. You will be tested on
material covered in class. You will be expected
to know the material and to be able to use it to
solve problems. Some problems will require you
to think creatively. You will not be tested on
material in the text that is not covered in
class. However, this material may be beneficial
in helping you understand the material covered in
class. Problem Sets Problem solving is an
indispensable part of the process of mastering
genetic principles and concepts. Klug Cummins
has a comprehensive set of genetics problems and
you are strongly encouraged to attempt to work as
many problems as possible. A Student
Handbook-Solutions Manual and Art Notebook is
available for the text. A copy of the Student
Handbook is on reserve in the Biological Sciences
- Pharmacy Library, Riffe Building. Problems of
particular relevance to the lecture material will
be pointed out at the beginning of each new
chapter. Additional Reference Materials An
Introduction to Genetic Analysis. Suzuki, D.T.,
et al. 7th Edition. 2000. W.H. Freeman and
Co. Genetics From Genes to Genomes. Hartwell,
et al. 1st Edition. 2000. McGraw-Hill
Co. Genetics Analysis of Genes and Genomes.
Hartl, D.L, Jones, E.W. 5th Edition. 2000.
Jones Bartlett. Genes VII. Lewin, B. 2000.
Oxford Univ. Press. These books, as well as the
textbook, are on reserve in the Biological
Sciences - Pharmacy Library.
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Introduction to Genetics Chapter 1 Problems
ALL
What is genetics? The science of studying
heredity!
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History of Genetics
Prehistoric Times
8,000 - 1,000 B.C. domesticated animals horse,
camels, sheep, oxen, dogs 5,000 B.C. cultivated
plants corn, wheat, rice 700 B.C. artificial
pollination date palm
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Greek Influence
Hippocrates (500-400 B.C.) humors Aristotle
(384-322 B.C.) vital heat physical substance
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Dawn of Modern Biology (1600-1850)
John Dalton Atomic Theory (1808) Schleiden
Schwann Cell Theory (1830s) Louis Pasteur No
spontaneous generation (1862)
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Theory of Evolution
Charles Darwin Voyage on the H.M.S. Beagle
(1831-1836) Galapagos Islands On the Origin of
Species (1859) Theory of Evolution Theory of
Natural Selection
Inheritance Patterns
Gregor Mendel (1866) Pea plant
experiments(1856-1863)
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20th Century

• DNA is the genetic material
• Griffith (1927)
• Avery, MacLeod, McCarty (1944)
• Hershey Chase (1952)
• DNA is a double helix
• Watson Crick (1953)
• Restriction enzymes discovered
• Arber, Smith, Nathans (1971)
• Polymerase Chain Reaction (PCR)
• Kary Mullis (1986)
• Human genome sequenced (2001)
• Inter. Human Genome Sequencing Consortium
• Celera Genomics

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Ways to study genetics

• Transmission genetics
• Cytogenetics
• Molecular genetics
• Population genetics

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Transmission genetics
The study of how genetic traits are transmitted
from one generation to the next.
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Cytogenetics
The study of chromosomes as units of inheritance.
Fig. 1.9
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Molecular Genetics
The study of the molecular processes underlying
gene structure and function.
Fig. 1.5
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Population Genetics
The study of how and why genetic variations are
maintained and lost in populations.
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Importance to Society

• Medicine
• Agriculture
• Forensic Science
• Human Genome Project