Department of Pharmacology Overview 20072008

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Department of PharmacologyOverview 2007-2008

• Heidi E. Hamm, Ph.D.
• Earl W. Sutherland, Jr. Professor of Pharmacology
• Chair, Department of Pharmacology

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Pharmacology Faculty
PHARMACOLOGY
Neuroscience Blakely Emeson Levitt Gurevich Shieh
Stanwood Konradi Current search Synaptic
electro-physiologist
Drug Discovery Conn Forster Weaver Lindsley Futur
e search DMPK with Clin Pharm
Clinical Pharmacology Roberts Brash Roden Oates Br
own Schneider Knollman Mundy Davies
Structural Biology Gurevich Hamm Iverson Spiller
Systems Biology Chung Brown Hamm Forster
Receptors Signal Transduction Hamm Sanders-Bush
Conn Gurevich Brown Barnett Wadzinski
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Pharmacology Recruitment

• 2007 Sean Davies
• 2008 Christine Konradi
• Current Recruitment neuroscience synaptic
  electrophysiologist
• Targets of opportunity Jon Schoenecker
• Ana Carneiro
• Carrie Jones
• Future Recruitments signal transduction
• cancer pharmacology
• drug disposition
• systems biology

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Our New Faculty Recruits

• Sean Davies studies the lipid products of
  oxidative stress, the isoketals
• He is a joint recruit with Clinical Pharmacology
• He recently received the 2007 NIH Directors New
  Innovator Award to develop better long-term
  treatment strategies for chronic diseases using
  probiotic bacteria engineered to produce
  therapeutic compounds.

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Our New Faculty Recruits

• Christine Konradi is a new Faculty Member in
  Pharmacology she joined us from the Psychiatry
  Department
• She trained in the Univ. of Vienna, the Univ. of
  Wurzburg, Univ. of Medicine and Dentistry of New
  Jersey, and the Mass General Hospital, Harvard
  Med. School.

• Christine works on the role of psychostimulants
  in
• gene regulation in psychiatric disorders
• She has two R01 grants

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How are we doing?

• Reputation
• Citations
• NIH funding
• National Responsibilities Honors
• Leadership roles

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Pharmacology Funding1998 - 2008
Weve had an incredible year!
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Pharmacology Funding withDrug Discovery
Highlighted
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Ratio of Awarded to Development
Spent(Average ROI is 8 awarded to every 1
spent in development)
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New Grants
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2007-8 Our Faculty Have Obtained National Grants
and Awards

• Craig Lindsley is PI on a MLPCN Chemistry
  Center Grant for 18M! This is one of only two
  in the country.
• He also has 2 new R01s

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National Grants and Awards

• Jeff Conn has received large grants from the
  Michael J. Fox Foundation for Parkinsons
  Research and from Seaside Therapeutics for
  studies of Fragile-X Syndrome
• He also has 5 R01 grants

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National Grants and Awards

• Randy Blakely received a NIMH Conte Center grant
  on Genes Controlling Assembly and Function of
  Serotonin Systems. Participants include Elaine
  Sanders-Bush, Pat Levitt, Ron Emeson, Doug
  McMahon and Evan Deneris
• Randy also has a R37 MERIT award, a R01 grant,
  and a PPG on Presynaptic Choline Transporters, as
  well as a training grant

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National Grants and Awards

• Heidi Hamm is part of a Specialized Center of
  Clinically Oriented Research (SCCOR) on
  Thrombosis from NHLBI to study Thrombin Signaling
  in Platelets
• She also has 3 R01s

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National Grants and Awards

• Alex Brown received a new Systems Biology of
  Infectious Disease Grant to study influenza
  virus interaction with its host, with Alan Aderem
  of the Institute for Systems Biology
• He also received the renewal of the Lipid MAPS
  Glue Grant

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National Grants and Awards

• Vsevolod Gurevich received a new grant from NIGMS
  entitled Conformational regulation of
  arrestin-mediated signaling
• He also has two other R01 grants

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National Grants and Awards

• Joey Barnett is a part of the Systems-based
  Consortium for Organ Design and Engineering
  (SysCODE)
• He also has an R01 and an AHA grant, as well as
  two training grants

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National Grants and Awards

• Brian Wadzinski renewed his NIGMS R01 grant on
  protein kinase/PP2A complexes
• He also has another R01 grant
• Eugenia Gurevich received a Michael J. Fox
  Foundation Grant

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National Grants and Awards

• Tony Forster received a Pilot Grant from the
  Vanderbilt Diabetes Center
• He also has an R01 and an ACS Research Scholar
  grant

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National Grants and Awards

• Tina Iverson received a NARSAD award on
  Allosteric Nucleotide Exchange in G protein a
  subunits
• She also has an R01 grant and a VICB pilot grant

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National Awards

• Randy Blakely 2008 ASPET Julius Axelrod Award
  2008 ASPET-Astellas Award in Translational
  Pharmacology

• Jeff Conn -- PhARMA Foundation Award for
  Excellence in Pharmacology and Toxicology

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National Awards

• Dan Roden -- 2008 Rawls Palmer Award for Progress
  in Medicine, American Society for Clinical
  Pharmacology and Therapeutics

• Joey Barnett -- AHA Southeast Affiliate Science
  Integration Award

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Our Faculty are Distinguished Leaders Nationally

• MERIT awards Randy Blakely, Elaine
  Sanders-Bush, Jack Roberts
• Editor of Molecular Pharmacology, Jeff Conn
• Associate Editors of Molecular Pharmacology, Alex
  Brown, Randy Blakely, Al George
• NIH Peer Review Advisory Committee, Heidi Hamm
• HHMI Review Board, Heidi Hamm
• President, American Society for Biochemistry
  Molecular Biology Heidi Hamm

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Our Faculty are Distinguished Leaders Nationally,
contd

• Pat Levitt NINDS Strategic Plan Committee
  Chair, High Risk/High Impact Program Committee,
  Autism Speaks Foundation NIMH Blue Ribbon Panel
  on Intramural Research Programs
• Joey Barnett -- co-chair April 2008 Pharmacology
  Education for the Next 100 Years, San Diego, CA
  Chair, American Heart Association Greater
  Southeast Affiliate Research Committee
• Alex Brown, Organizer/Chair for FASEB meeting on
  Phospholipases, July 2008

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Our Faculty are Distinguished Leaders Nationally,
contd

• Heidi Hamm -- Member, FASEB Science Policy
  Committee Peer Review Subcommittee Board
  Advisor, FASEB Excellence in Science Awards
  Committee, 2007-08 Member, AAMC Panel on Safe
  and Effective Prescribing Practices
• Jeff Conn Chair, Division of Neuropharmacology,
  ASPET Scientific advisory board member, Stanley
  Center for Psychiatric Research, Broad Institute
  Technical Evaluation Panel, NIMH Program Review

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Our Faculty Receive Kudos at home

• Jeff Conn named Lee E. Limbird Professor of
  Pharmacology

• Nancy Brown - 2008 Elaine Sanders-Bush Faculty
  Award for Mentoring

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Our Faculty Receive Kudos at Home

• Joey Barnett was elected to the Vanderbilt
  Academy for Excellence in Teaching

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Our Faculty are Campus Leaders

• Randy Blakely - Director, Center for Molecular
  Neuroscience, Director, Vanderbilt/NIMH Silvio O.
  Conte Center for Neuroscience Research
• Pat Levitt Director, Kennedy Center
• Jeff Conn - Director, Program in Drug Discovery,
  Director, Program in Translational
  Neuropharmacology
• Dan Roden - Director, Oates Institute of
  Therapeutic Discovery, Asst. Vice-Chancellor for
  Personalized Medicine, Principal Investigator,
  Vanderbilt DNA Database
• Jack Roberts Faculty Senate Vice Chair-Elect

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Our Faculty are Campus Leaders, Continued

• Nancy Brown - Associate Dean for Clinical and
  Translational Scientist Development, Director,
  Vanderbilt (K12) Clinical Research Scholars
  Program
• Heidi Hamm - Internal Advisory Board, Vanderbilt
  University Vanderbilt Institute for Clinical and
  Translational Research, CTSA Medical Scientist
  Training Program Faculty Advisory Committee
• Ron Emeson Chair, Institutional Animal Care and
  Use Committee University Faculty Senate Academic
  Programs and Services Committee
• Tina Iverson serves on the Center for Structural
  Biology Executive Committee, as well as the
  Chemical Biology Interface Training Grant
  Executive Committee
• Gregg Stanwood is Associate Director, Vanderbilt
  Mouse Neurobehavioral Core

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Study Section Members

• Full Members
• Joey Barnett
• Randy Blakely
• Alex Brown
• Chang Chung
• Seva Gurevich
• Ron Emeson
• Craig Lindsley
• Christine Konradi

• Ad-hoc Members
• Tony Forster

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We are Highly Cited

• Vanderbilt ranks 5 in The Most-Cited
  Institutions in Pharmacology Toxicology,
  1996-2006

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A New Faculty Scholarly Productivity Index

• The index uses only objective criteria to
  calculate the scholarly productivity of
  individual faculty.
• It rates faculty members' scholarly output at
  nearly 7,300 doctoral programs around the
  country.
• The index was devised by Lawrence B. Martin,
  graduate dean at the State University of New York
  at Stony Brook.
• It uses faculty publications, citations, awards
  and grants which it obtains from the web.

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In 2007, Vanderbilt Pharmacology Ranks 6 in the
Country

• Use of the objective criteria of faculty
  publications, citations, awards and grants makes
  clear how strong our faculty are.
• Main difference this year is of faculty they
  found 100 this year, 45 last year

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Goodbye, well miss you

• Pat Levitt - Director, Vanderbilt Kennedy Center
  will be moving in June 2009 to become the
  Director of the Zilkha Neurogenetic Institute,
  Chair of Cell and Neurobiology

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Goodbye, well miss you

• Lou DeFelice has gone to Virginia Commonwealth
  University to be Director of Graduate Studies in
  Physiology and Biophysics and Assistant Dean for
  Graduate Education

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Our Challenges

• Managing fast growth puts stress on faculty,
  administration, space
• Funding in a flat NIH environment faculty need
  to be ever more adventuresome about finding
  funding bridge funding is SO appreciated!
• Economic crisis affects us all, individually, the
  department, the institution.

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Pharmacology Administrative Headcount