neuroimaging of reading at Haskins

1
neuroimaging of reading(at Haskins)
2
people
Pawel Skudlarski Cheryl Lacadie R. Todd
Constable Doug Whalen Cathi Best Donald
Shankweiler Leslie Jacobsen Carol Fowler ...
Ken Pugh Steve Frost Jay Rueckl Len Katz Nicole
Landi Helen Chen Rebecca Sandak Gina Della
Porta Kelley Delaney Eleanor Tejada
3
outline

• - theory
• - occipitotemporal area
• correlational analysis
• repetition effects

4
theory

• Initial model - Pugh et al., 2001

• Hypothesized Role of component circuits
• Phonological
• IFG
• SMG/STG
• Semantic
• MTG/ITG
• AG
• Putative Visual word form Area
• OT/VWFA
• Skill Zone is phonologically and
  morphologically tuned

5
occipitotemporal regionVisual Word Form Area
activations in Shaywitz et al. 2002 older good
readers 74 good readers 7-18 yrs 70 dyslexic
readers 7-18 yrs
6
Functional Connectivity
activations in Shaywitz et al. 2002 older good
readers 74 good readers 7-18 yrs 70 dyslexic
readers 7-18 yrs
7
Functional Connectivity
seed voxel correlations older good readers
8
Functional Connectivity
univariate correlations
Older Non-Impaired
9
Functional Connectivity
Younger Non-Impaired
Older Non-Impaired
univariate correlations
Older Dyslexics
Younger Dyslexics
10
repetition effects?
Learning Curve Hypothesis Activation levels
follow an inverted-U shaped function with respect
to familiarity and/or skill in processing, words.
good readers
poor readers, high-freq words
U
good readers, high-freq words
poor readers
gt activation gt
good readers, repeated words
gt familiarity gt
11
simple response to printed words
good readers poor readers
12
repetition effect
good readers poor readers
13
characterization
good versus poor readers, repetition
effect yellow areas reduce in good readers,
increase in poor readers
14
characterization
good versus poor readers, repetition
effect yellow areas reduce in good readers,
increase in poor readers
15
characterization
activation levels in superior temporal gyrus by
presentation numbers 1-6, and subject group

16
characterization
activation levels in inferior frontal gyrus by
presentation numbers 1-6, and subject group

17
people
Pawel Skudlarski Cheryl Lacadie R. Todd
Constable Doug Whalen Cathi Best Donald
Shankweiler Leslie Jacobsen Carol Fowler ...
Ken Pugh Steve Frost Jay Rueckl Len Katz Nicole
Landi Helen Chen Rebecca Sandak Gina Della
Porta Kelley Delaney Eleanor Tejada
18
peepo
Pawel Skudlarski Cheryl Lacadie R. Todd Constable
Ken Pugh Steve Frost Jay Rueckl Len Katz Nicole
Landi Helen Chen Rebecca Sandak Gina Della
Porta Kelley Delaney Eleanor Tejada
supported by NIH grants HD-01994 (A-40, C.
Fowler) and HD404119 (A-107, K. Pugh)