Current Topics

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Current Topics in Monte Carlo Treatment
Planning McGill University, Medical Physics
Unit May 3-5, 2004, Montreal, Quebec, Canada
Radovan D. Ilic, Vesna Spasic-Jokic, Petar
Belicev and Milo Dragovic
Institute of nuclear sciences Vinca TESLA
Accelerator Installation www.tesla-sc.org www.vin.
bg.ac.yu/rasa/hopa.htm
The Monte Carlo SRNA-VOX code for 3D proton dose
distribution in voxelized geometry using CT data
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GENERAL-PURPOSE MONTE CARLO PROGRAM SRNA FOR
PROTON TRANSPORT SIMULATION
  
Proton therapy Accelerator driven system design
Radioisotopes production for medical
applications Simulation of proton scatterer and
degrader shapes and composition Radiation
protection of accelerator installations
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SRNA-2KG attributes
  Original author Radovan D. Ilic, Ph.D, VINCA
Institute of Nuclear Sciences, Physics
Laboratory General Purpose Numerical experiments
for proton transport, radiotherapy and
dosimetry Secondary particles protons
transported as the protons from source Proton
energy range 100 keV to 250 MeV Material
Database 279 elements Z 1-99, compounds and
mixtures 181, limited by available ICRU63 cross
sections data Material geometry 3 D zones
described by I and II order surfaces or in 3D
voxelized geometry Program Language Fortran 77
for Linux or Windows
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SRNA-VOX MONTE CARLO CODE
Simulation model . Multiple scattering theory
of charged particles (Moliere angular
distribution, Berger) . Energy loss with
fluctuation (ICRU49 functions of stopping power,
Vavilov's distribution with Schulek's
distribution correction per all electron orbits )
. Inelastic nuclear interaction (ICRU 63, Young
and Chadwik 1997) . Compound nuclei decay (our
simple and Russian MSDM models) . CT numbers
describing 3D patients geometry . Correlation
between CT numbers and tissue parameters
mass-density and elemental weight Numerical
experiments setup . Energy range from 100 keV
to 250 MeV . Materials limited by available
ICRU63 cross sections data . Circular and
rectangular proton sources in 4Pi with applied
spectra . DICOM picture and sampling region for
irradiation . Probabilities and data preparation
by SRNADAT code . 3D dose presentation on patient
anatomy
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Comparison of the SRNA package
Comparison of proton depth dose distribution
obtained from Monte Carlo numerical
experiments by SRNA-2KG and GEANT-3
codes Comparison of proton depth dose
distribution obtained from Monte Carlo numerical
experiments by SRNA-2K3 and GEANT-4
codes SRNA-2KG, GEANT3, SRIM Simulation and MLFC
measurements at 205 MeV proton Indiana Univ.
Cycl. Facility, IUCF, USA Intercomparison of the
usage of computational codes in radiation
dosimetry, Bologna, Italy, July 14-16 2003
 
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Multi layer Faraday Cup (MLFC) experiments
 WHY To specify the proton beam from
accelerator and verify the quality and
reproducibility of the proton beam for the proton
therapy. WHO Indiana University Cyclotron
Facility HOW Monte Carlo simulation by SRIM,
SRNA-2KG and GEANT3 data compared with actual
measurement data RECOMMENDATION A simple test
for nuclear interaction model can be checked by
MLFC. Every Monte Carlo code to be used in
charged particle therapy should pass this test
(Paganetti)
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SRNA-2KG, GEANT3, SRIM Simulation and MLFC
measurements at 205 MeV proton Indiana Univ.
Cycl. Facility, USA
Mascia A.E., Schreuder N., Anferov V. August 2001
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QUADOS, Bologna 2003 Uvea melanoma
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A parallel beam of protons from a disk source
(diameter 15 mm) impinges on a PMMA compensator
(cylindrical symmetry) and on a spherical water
phantom approximating an eye (figure 1). All
elements are in vacuum. If discrete regions are
used for dose calculations (depth-dose and
isodose curves), use voxels with dimensions 0.5 x
0.5 x 0.5 mm3. The results should be normalized
to one primary proton
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INTERCOMPARISON OF THE USAGE OF COMPUTATIONAL
CODES IN RADIATION DOSIMETRY Bologna, Italy, July
14-16 2003
Stefano Agosteo Dipartimento Ingegneria
Nucleare,Politcnico Milano, Italy
S Fluka 2002 P3-F srna-2kg
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SRNA-VOX Deposited proton energy in eye
50 MeV circular proton beam with 1.2 cm radius CT
data slice thickens 0.5 cm pixel dimension
0.081 cm
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SRNA-VOX 1E6 PROTONS ltEgt80 MeV SPREAD5 MeV
20 80 95 100
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ISTAR proton dose planning software
Trends in proton therapy planning Development
of the Monte Carlo proton transport numerical
device capable of producing a therapy plan in
less than 30 minutes and Development of
clinically acceptable on-line procedures
comprising all steps necessary for proper patient
treatment. ISTAR software solved the first of
these problems Why ISTAR ?
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DUNAV ISTAR - DJERDAP
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LEPENSKI VIR LANDSCAPE
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LEPENSKI VIR CULTUREMOTHER
DANUBIUS
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PROTON DATA PLANNING window
Picture Planning Data - information about the
boundaries of the space selected for simulation
Beam geometry with fields for selection of
the beam shape (rectangular or cylindrical) and
dimensions, Euler angles defining the direction
of the beam axis with respect to the selected
"Beam center", and polar and azimuthally angles
of the proton emission within the local SRNA-VOX
coordinate system Simulation setup with
fields for selection of proton energy (mean
energy and standard deviation for Gaussian
distribution, or custom defined spectrum),
simulation cutoff energy, number of proton
histories and the simulation time limit. The
result of these actions is written in two files
(i) Hound.txt containing data about the defined
region, proton source and Houndsfield's numbers
for all voxels of the region (ii) Srna.inp with
the setup data for simulation.
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ISTAR - Proton dose planning software
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ISTAR - Proton dose planning software
Choosing a rectangle around the region for proton
dose simulation
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ISTAR - Proton dose planning software
Choice of the first and last slice, and beam
center
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ISTAR - Proton dose planning software
Final CT and geometry data selection, and making
files for set-up the proton dose simulation
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Dose distribution in equatorial eye plane,
simulated by the SRNA-VOX code, using 50 MeV
protons with 1.2 MeV energy spread. The isodoses
are at the values of 20, 60, 80 and 100 of dose
maximum.
20 60 80 100
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ISTAR advantages
- The software is based on the knowledge and
experience acquired in working on the SRNA - It
is capable to accept CT data for defining
patients anatomy and tissue composition - A
simple procedure for selecting the irradiation
area and incident proton beam parameters allow
fast and comfortable calculation of the dose
distribution and visualization of it in each CT
recorded slice of the patients body. - Execution
time is short enough to be introduced in clinical
practice. - The statistical error of the
obtained results can be made almost arbitrary
small by simple increase of the number of the
proton histories to a few millions, without
exceeding e.g. 30 min as acceptable computer run
time.
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CONCLUSION
SRNA package advantages Enlargement of the
proton energy range, Increasing the efficiency
of the implemented algorithms in order to
Decrease the time necessary for proton transport
simulation. Motivation for ISTAR proton dose
planning software development were good results
of verification of SRNA package.

 
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Building of the TESLA accelerator installation
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TESLA accelerator installation (Layout)
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PROGRAMS OF TESLA AI

• Construction of TAI
• Construction of the VINCY Cyclotron
• Construction of the experimental channels of TAI
• Use of TAI
• Modification of materials by ion beams
• Radiation research
• Physics of thin crystals and nanotubes
• Production of radioisotopes and
  radiopharmaceuticals
• Proton therapy
• Neutron research
• Physics of hadrons and electroweak interactions
• Physics of hadrons at medium energies
• Physics of electroweak interactions and medium
  and high energies

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pVINIS Ion Source
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mVINIS Ion Source
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Magnetic structure of the VINCY Cyclotron
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Channel for modification of materials L3A
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The future activities in the upgrading of the
ISTAR software assume introduction of
visualization of the dose distribution over a 3D
transparent model of the patient body.