The caBIG Strategic Plan

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The caBIG Strategic Plan

• J. Robert Beck, M.D.
• For the Strategic Level Strategic Planning
  Working Group of the Cancer Biomedical
  Informatics Grid

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What is the caBIG Community?

• A Community of Communities
• Sharing Common Interests
• Data Standards
• Sharable and Interoperable Architectures
• Informatics Tools
• Cancer Research
• To the Ultimate Benefit of Patients

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caBIGs Five Year Mission

• Develop Standards, Tools, and Prototypes
• Bias Toward Action and Interaction
• Easy Methods of Dissemination
• Open Source
• Open Access
• Open Development
• Federation

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Workspaces and Working Groups
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A Focus on Interaction
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Scenario, 2008

• A researcher involved in a phase II clinical
  trial of a new molecularly targeted therapeutic
  for brain tumors observes that cancers derived
  from one specific tissue progenitor appear to be
  strongly affected. The trial has been generating
  proteomic and microarray data. The researcher
  would like to identify potential biochemical and
  signaling pathways that might be different
  between this cell type and other potential
  progenitors in cancer, deduce whether anything
  similar has been observed in other clinical
  trials involving agents known to affect these
  specific pathways, and identify any studies in
  model organisms involving tissues with similar
  pathway activity.

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Today vs 2008?

• In 2005 such a study would involve immense
  manual work getting information locally and from
  other sites, precluding the possibility of
  identifying the required data and thus being
  unable to deduce the likely significance of the
  trial observation. However, with caBIG
  compliant components now under development, the
  researcher would be able to perform the analysis
  routinely, with data flowing through systems and
  analysis being automatic. This analysis will
  yield biomarkers and potential drug targets
  gathered from multiple workspaces and make it
  possible to develop treatment modalities faster,
  less expensively, and more effective for
  patients.

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Discovery utilizing caBIG Integrated Cancer
Research Tools
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Overall Goals for caBIGShort-term (December
2005)

• Develop first generation caBIG compliant tools
  and data sets and supporting data and
  architecture standards.
• Promulgate Gold, Silver, and Bronze development
  project standards to national cancer research
  community.
• Establish a mechanism for engaging the private
  sector, cancer research organizations not
  currently contracted under caBIG, and other
  Federal agencies and divisions into the caBIG
  community.
• Publish white paper on Mission and Goals of caBIG
  aimed at a broad audience.

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Overall Goals for caBIGThree-year (mid-2008)

• Develop sufficient research tools and standards
  to have a positive impact on the cancer research
  community, as measured by adoption of relevant
  caBIG principles in project proposals.
• Ensure widespread adoption of developer standards
  so that funded developer projects are operating
  under the Gold standard of compatibility.
• Adopt and use caBIG interoperable tools and data
  sets within the caBIG community.
• Develop mechanisms for engaging and promoting
  caBIG compliant technologies and established
  datasets within the oncology research community.

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Overall Goals for caBIGFive-year (mid-2010)

• Ensure widespread adoption, dissemination, and
  use of caBIG interoperable tools, standards, and
  data sets within the larger cancer community, to
  include the biopharmaceutical industry, non-NCI
  cancer centers, and the national cancer research
  enterprise.
• Begin to see results of caBIG-compliant
  interdisciplinary and inter-institutional
  research affecting clinical oncology care.

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Workspace Goals

• Clinical Trials Management Systems
• Integrative Cancer Research
• Tissue Banks and Pathology Tools
• Architecture (cross-cutting)
• Vocabulary and Common Data Elements
  (cross-cutting)

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Architecture

• Conceptually, caBIG has adopted two primary
  guiding principles
• To bring systems on-line quickly, caBIG is
  committed to a bias for action. This implies a
  commitment to making decisions and moving
  forward, even if perfection cannot be achieved.
• To allow long-term evolution and improvement of
  architectural design, caBIG is committed to
  designing for change.
• To turn these thoughts into action, caBIG has
  also adopted a two-pronged practical approach
• If requirements are well-understood and good
  solutions are available, caBIG initiates
  developmental activities within the architectural
  workspace.
• If requirements are less clear or if solutions
  are not yet available, caBIG commissions analysis
  and assessment activities.

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Service-Oriented Architecture
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Mapping caBIG Compliant Applications to the Grid
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Architecture Goals
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Vocabulary and Common Data Elements
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Clinical Trials Management Systems
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Integrative Cancer Research
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Tissue Banks and Pathology Tools
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Data Sharing and Intellectual Capital
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DSIC Goals
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Training Working Group
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Training Goals
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caBIG Strategic Planning An Ongoing Activity,
a Living Document

• Incorporation of new workspaces
• New projects, new technologies
• Opportunity for pathology informatics in
  several work areas

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The SPSLWG

• Joyce Niland Doug Stahl Lincoln Stein
  Michael Townsend
• Amin Chisti Daniel Geraghty Bob Robbins
  Donald Berry
• John Cook Marcella Johnson Maurie Markman
• DeLynn Shetter David Stivers Ken Buetow
  Peter Covitz
• Mary Jo Deering Leslie Derr Sue Dubman
  Gene Levinson
• Deborah Collyar JoAnne Ruh Clayton Naeve
  Seng-jaw Soong
• Jessica Bondy Terry Braun Thomas Casavant
• Kim Johnson Bob Beck Frank Manion
  Michael Ochs
• Howard Bilofsky David Birtwell David
  Fenstermacher
• Mike Becich Valerie Monaco Jeffrey Bond
  John Casagrande
• Jeffrey Milbrandt Rakesh Nagarajan Mark
  Watson
• Mark Adams Theo Wills Chalk Dawson
• David Tuck Thomas Caruso Bob Annechiarico
  Emily Allred
• Greg Bielawski Joel Saltz John Speakman