ZONE DIET

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TREATMENT OFIRRITABLE BOWEL SYNDROMEBY THE ZONE
DIET

• Anthony J Dowell
• MB,BS, MSc, FACS, FRCS(C)
• Nanaimo Regional General Hospital

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IRRITABLE BOWEL SYNDROME

• Chronic functional disorder
• Symptoms well known
• Cause obscure
• Treatments unsatisfactory
• Prokinetic antkinetic agents variably
  effective suggests motility disorder neuronally
  or hormonally mediated.

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• 1800 less than 1oz/day
• 1900 2oz/day
• 1950 5oz/day (3lb sugar beet, 24 apples)
• 2000 8oz/day (180 lb/year)

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ZONE DIET

• Current healthy diets restrict sugar and refined
  carbohydrate
• Human gut has not had time to adapt to
  carbohydrate load since agricultural and
  industrial revolution
• Zone diet takes this a step further by using diet
  to tightly control blood levels of major
  hormones, principally insulin.
• Insulin a storage hormone, stores incoming
  calories as fuel for future use (fat)
• Zone diet aims to control insulin levels within a
  tight zone by allowing a fairly constant
  absorption of low-glycaemic carbohydrate

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• 80 of ability to control insulin levels diet
• 20 - exercise

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ZONE DIET I.B.S.

• PILOT STUDY 1 year
  
• 35 patients
• All female, 35-75
• Abd symptoms/pain, clinically IBS
• TESTS stepwise approach (Univ of Alberta)
• - minimize, R/O other causes
• constipation/diarrhea
  predominant pain
• ZONE DIET - informed consent
• - prospective
• - randomized
• - follow up complete

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RESULTS

• Compliance 26/35
• Unchanged 0/26
• Improved 10/26
• Much Better 16/26

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DISCUSSION

• Numbers small, trend seems very apparent
• No statistical analysis would be appropriate
• Real or placebo effect?
• Original observation
• No other published literature linking diet or a
  hormonal mechanism with IBS
• Crohns disease treated with growth hormone
• Confirmatory studies underway Victoria

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CONCLUSIONS

• Symptoms of IBS seem to improve by controlling
  production of GI hormones, principally insulin,
  by The Zone Diet.
• IBS may be hormonally mediated in response to
  excess dietary sugar refined carbohydrate.
• This has not been suggested before.
• The best treatment for the condition may be cheap
  and plentiful, and is called food.
• Clinical trial would seem worthwhile to test
  this.
• Fundamental research is planned.

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