Title: Cell Junctions and extra cellular matrix II
1Cell Junctions and extra cellular matrix II
2Desmosomes and hemidesmosomes both link to
intermediate filaments
3Cadherins also bind intermediate filaments
together
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5Integrins link extracellular matrix to
cytoskeleton
6Size of gap junction channel can be determined
with fluorescent molecules of different sizes
7A Gap junction connexon is made up of 6
transmembrane connexin subunits
8Images of gap junctions
9The permeability of gap junctions can be regulated
dopamine treatment reduces permeability of gap
junctions to a fluorescent dye
10Summary of cell junctions found in the cell
11Summary of cell junctions found in the cell
12In plant cells plasmodesmata perform many of the
same functions as gap junctions
13View of plasmodesmata
14Structure of Cadherin responsible for cell to
cell adhesion in vertebrate cells
15Ca2 is required to establish cell to cell
connection through cadherin
16Three mechanisms that mediate cell-cell adhesion
cadherins
least common
17Cadherins allow cells to sort themselves
18Catenins join cadherins to actin filaments in
adherence junctions
19Summary of junctional and non-junctional adhesive
mechanisms
20Cells surrounded by extracellular matrix
21Cross sectional view of intestinal wall
22Connective tissue underlying the epithelium
contains a variety of cells and extracellular
matrix components
23Fibroblasts surrounded by collagen fibrils
24Glycosaminoglycan (GAG) chains occupy large
amounts of space and form hydrated gels
25Hyaluronan, a simple GAG, occupies a large amount
of space, thereby providing mechanical support
26Repeating disaccharide unit of hyaluronan
27GAG and its core protein form proteoglycan
28Comparison of proteoglycans with a ribonuclease
29picture of aggrecan aggregate, a large
proteoglycan
30structure of Aggrecan aggregate
31Collagen fibril embedded in proteoglycan molecules
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33Fibroblast surrounded by collagen fibrils
34Collagen fibrils in tadpole skin
This arrangement is also found in bone and the
cornea
35Elastic fibers in a dogs aorta
36Each elastin protein in the network can expand
and contract as a coil
37Fibronectin is an extracellular protein that
helps cells attach to the matrix
38Connective tissue underlying the epithelium
contains a variety of cells and extracellular
matrix components
39basal lamina in the cornea of a chicks embryo
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41A model of the basal lamina
42Cross Section of Kidney
43Filtration is one step in urine formation
44Structure of Nephrons
45Inside Bowmans Capsule
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48Basal Lamina plays an important role in filtration