Actinomycetes

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Actinomycetes

• Page 6

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Actinomycetes (order)

• Three genera
• Actinomyces species
• Nocardia species
• Streptomyces species

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Gram Positive Filamentous Bacteria
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Actinomycosis

• A chronic suppurative and granulomatous disease
  of the cervico-facial, thoracic or abdominal areas

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Actinomycosis

• Actinomyces israelii

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Ecological Niche

• Actinomyces
• Endogenous
• (man and animals)

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CLINICAL SPECIMENSActinomyces

• Pus

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Sulphur granules
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Drug of Choice

• Penicillin
• (large doses)

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Serological Test

• None available

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Nocardiosis

• Subcutaneous infections, pulmonary infections,
  and brain abscesses

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Ecological Association

• Soil
• Endogenous ?

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Geographic Distribution

• World wide

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Nocardiosis

• N. asteroides Pulmonary
• N. brasiliensis - Abscesses

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Clinical Specimens

• Sputum
• Pus
• Biopsy tissue

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Serological Test

• None available

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Drug of Choice

• Sulfamethoxazole-Trimethoprim

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STREPTOMYCOSIS

• Streptomyces species

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Mycetoma

• Streptomyces species

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Ecological Association

• Soil

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Streptomyces may invade bone
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Clinical specimens

• Pus
• Biopsy material

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Serological Test

• None available

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Treatment

• Surgical debridement
• Sulfa drugs
• Amphotericin B

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