Dr. Horst Hemmerle

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Dr. Horst Hemmerle

• Eli Lilly Company
• Director Lead Generation Technologies
• Responsible for
• Compound Collection Enrichment Strategy
• Screening Strategies Target families
• DCRT Technologies /Automation
• Chemoinformatics/Chemogenomics

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Solving Complex Issues
Prostate Cancer
Disease mechanism
Cellular mechanism
Angiogenesis
Apoptosis
Informatcis platforms allow integration and
creation of knowledge
VEGF
FAS
Molecular mechanism
compounds
Annotated chemical diversity
Targets
Analysis Predictions - Simulations
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Library Deliverables

• Hits/Leads/Back-up Scaffolds

MTS of selected cassettes forDrug Discovery
efforts

• Validation Tools (Hits,Fragments)
• Ligands to Explore Polypharm

Selected sets forTarget of Interest evaluation
Dynamic Library
compounds
data
Iterative Screen Panels Kinases GPCRs NHRs Ion
Channels Proteases Lipases Transporters
Active Compounds and Information