Antioxidant activity of resveratrol

1
Antioxidant activity of resveratrol
2

• Resveratrol possesses antioxidant properties
  and reduces ROS generation In blond platelets.
  During platelet activation, ROS are produced in
  the receptor-mediated signalling pathways due to
  arachidonic acid metabolism by cyclooxygenaze or
  lipoxygenase, the glutathione cycle, metabolizm
  of phosphoinositides and due to xanthine oxidase
  and NADPH oxidase. ROS induce changes in
  intraplatelet Ca2 and may behave as second
  messenger in thrombin- or collagen-activated
  platelets. ROS generation has been proposed as
  critical signals in regulating of platelet
  activity.

3

• The use of the chemiluminescence method for
  assessing the level of reactive oxygen species in
  platelets and the method of reduction of
  cytochrome C for the estimation of the level of
  O2- showed that resveratrol at high
  concetrations has antioxidative action on resting
  blood platelets and platelets activated by
  thrombin, TRAP or LPS from Proteus mirabilis.

4

• Antioxidtaive action of high concetrations of
  resveratrol can minimise the risk of various
  illness and it my be beneficial in protecting
  against coronary heart diseases when
  hyperactivity of platelets is observed. Frankel
  et al. reported that the ability of wines to
  protect low density lipoproteins LDL from
  oxidation appears to be dependent not only on
  resveratrol but also due to phenolic substances
  abundant in wine. These compounds as antioxidants
  seem to be helpful in inhibiting of LDL
  oxidation and in reducing the incidence of
  coronary heart disease and arteriosclerosis.

5

• Resveratrol inhibits lipid peroxidation mainly
  by scavenging peroxyl radicals. There is evidence
  that resveratrol may partly reduce the formation
  of nitrotyrosine in plasma and platelet proteins
  and partly inhibit thiol oxidation in blood
  platelets treated with exogenous peroxynitrite
  ONOO- yields 30-35 of carbonate radical CO3-
  and nitrogen dioxide NO2, which are also strong
  oxidants phenols are the efficient scavengers of
  CO3- and NO2.

6

• Resveratrol may augment antioxidative
  properties of orther dietary agents, e.g., a
  combination of resveratrol and vitamin C has been
  shown to exhibit greater protective activity
  against oxidative stress in cells than any of the
  antioxidants alone. Moreover, we did not observe
  any synergistic action of resveratrol and vitamin
  C on oxidative stress in blood platelets.