Genomic Pathology: One Gene, One Disease, One Medicine

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Genomic PathologyOne Gene, One Disease, One
Medicine

• Robert D. Cardiff, M.D., Ph.D.
• Director
• Center for Genomic Pathology
• Center for Comparative Medicine
• Department of Pathology and Laboratory Medicine
• University of California, Davis
• http//ctrgenpath.org

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myc
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Gene-Specific Breast Cancer Phenotypes
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GEM PROSTATE TUMORS That Mimic Human
A
B
SPONTANEOUS HUMAN
Induced by MYC
WHICH IS HUMAN? A or B?
Elwood-Yen PMID 14522256
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Genomic Medicine

• The human genome is sequenced
• The genetic code has been broken
• The function of each gene will be determined by
  phenotyping (Phenogenomics)
• The phenotypes will be induced in Genetically
  Engineered Mice (GEM)

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The mouse is a powerful model for human genomics

• Genomics will revolutionize medicine.
• Mouse mutants provide the most durable and high
  throughput means of understanding human genomic
  biology.
• Mouse models represent the virtual Kochs
  Postulates of modern biology.

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What is Genomic Pathology?

• The genome has been sequenced.
• The function of each gene needs to be elucidated
  by phenotyping. (Phenogenomics)
• Genes are associated with diseases. Diseases
  require microscopic validation.
• (Genomic Pathology)
• Gene phenotyping starts with the mouse, analyzed
  by Genomic Pathologists.

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Far too many devastating, costly errors in the
literature!
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The Impending Crisis

• Industry, NIH and other international agencies
  are generating huge numbers of genetically
  modified mice. (20,000 -200,000 new strains)
• Mouse mutant phenotypes are often inadequately
  characterized or misinterpreted.
• Not enough existing comparative pathologists to
  meet this need.

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Documenting the critical shortage

• The PRIME and ACVP reports
• Few experimental mouse pathologists
• Few experienced with multiple mouse lines.
• Necropsies often done without benefit of trained
  pathologists.
• Workers often lack appropriate qualifications.

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The Solution

• A coordinated system to share information and
  access available comparative pathology resources.
• A world-class faculty
• Streamlined interactive training of future
  generations of comparative pathologists.
• Proper training of all levels of
  parapathologists.
• Economical Web-based training programs
• Proper certification of Trainees.

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How do I Learn aboutGenomic Pathology?
http//ctrgenpath.net
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GENOMIC PATHOLOGYDivisions of Course
Workoffered over the Internet

• LEVEL ONE BIOLOGY OF LABORATORY MICE
• DESIGNED For graduate students, fellows and
  technical staff
• GOAL To train the student to more effectively
  and accurately perform studies using a mouse
  model. Emphasis on identification of gross and
  microscopic features of the healthy and diseased
  animals
• LEVEL TWO PATHOLOGY OF GENETIC ENGINEERED MICE
  (GEM)
• DESIGNED For persons with advanced degrees and
  Level I graduates
• GOAL To provide training in the biology and
  pathology of GEM for PIs.
• LEVEL THREE ADVANCED STUDIES OF GEM
• DESIGNED For certified veterinary and medical
  pathologists
• who desire advanced study on GEM
• GOAL To provide graduate information on
  specific pathologic changes seen in many GEM
  strains. To prepare the pathologist to become
  competent in evaluating these unique changes both
  gross and microscopically.

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CGP Faculty

• James M. Crawford, M.D., Ph.D. Chairman of
  Pathology and Editor in Chief Lab Investigation
  (229 PubMed publications)
• Stephen W. Barthold, D.V.M.. Ph.D. Professor and
  Director, Member NAS (211 PubMed publications),
  Co-author Percy and Barthold Rodent Pathology.
• Rod Bronson, D.V.M. (471 PubMed publications)
• Robert D. Cardiff, M.D., Ph.D., Distinguished
  Professor, Former Chair of UCD Pathology, Former
  UCD Director of Medical Informatics AAAS Fellow
  (234 PubMed publications)
• Murray B. Gardner, M.D., Professor Emeritus,
  Former Chair UCD Pathology. AAAS Fellow (245
  PubMed publications)
• VE Ted Valli, D.V.M., M.Sc., Ph.D. Former Chair
  of Pathology, Guelph, Former Dean Illinois
  College of Veterinary Medicine (225 PubMed
  publications)
• Jerrold M. Ward, D.V.M., Ph.D. (566 PubMed
  publications)
• Robert R. Maronpot, D.V.M. (273 PubMed
  publications)
• See http//ctrgenpath.net for all CGP members

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LEVEL ONE
60 Hours of PPT
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THE END
http//ctrgenpath.net
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