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Psychobiology of PTSD

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Title: Psychobiology of PTSD


1
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2
Providing care to OIF/OEF veterans
  • Steve McCutcheon, PhD
  • Matthew Jakupcak, PhD
  • VA Puget Sound Healthcare System, Seattle
  • Department of Psychiatry and Behavioral Sciences,
  • University of Washington School of Medicine

3
Acknowledgments
  • Miles McFall, PhD
  • Director, Psychology Service
  • Director, PTSD Patient Care Line
  • VA Puget Sound Health Care System

4
Workshop overview
  • Basic epidemiology and patient characteristics
  • A model of integrated care for OIF/OEF veterans
  • Federal and State collaboration in Washington
    State
  • An integrated model of primary stepped care at VA
    Puget Sound, Seattle
  • Adapting evidence-based PTSD treatments in
    secondary prevention efforts for OIF/OEF veterans

5
Faces of the war
  • James
  • Avoidance and withdrawal
  • Gary
  • Vigilance and control

6
Facts about the war
7
War in Southwest AsiaPopulation Statistics
  • Over 1,000,000 military personnel deployed to
    Southwestern Theater of Operation
  • 505,366 veterans have left active duty (as of
    12/31/05)
  • 43 active duty troops
  • 57 Reserve and National Guard
  • VHA Office of Public Health and Environmental
    Hazards, February 14, 2006

8
War in Southwest AsiaHuman Costs
  • 2,513 Americans killed (2/7/06)
  • 17,096 officially wounded (2/7/06)
  • 50,000 250,000 civilians killed (Nov. 2004)

9
Top 10 Causes of OIF Deaths 3/19/2003
11/30/2004
10
Increasing Survival Rate of Injured Soldiers
  • WWII 23 of injured combatants died
  • Vietnam 17 of injured combatants died
  • Iraq/Afghanistan 9 of injured combatants die
  • As many US soldiers have been injured in combat
    thus far in Iraq/Afghanistan as were in the
    Revolutionary War, the War of 1812 or the first 5
    years of the Vietnam War
  • Gawande A. Casualties of WarMilitary Care for
    the Wounded from Iraq and Afghanistan. NEJM
    351(24) 2471-2475.

11
Combat Exposure for OIF SoldiersHoge et al.
(2004)
12
Service utilization
13
Perceived Barriers to Mental Health CarePositive
Screen Cases Hoge et al. (2004)
14
Utilization of Mental Services Active Duty
Personnel
  • Only 23 of positive screen active duty Army/USMC
    personnel sought mental health care in past year1
  • 35 soldiers in a population-based study sought
    mental health services in first year after
    demobilization2
  • 1Hoge et. Al. 2004
  • 2Hoge et. Al. 2004

15
Utilization of VA Services
  • 29 (144,424) have sought VA care nationally
    (12/31/05)
  • 32 of separated active duty
  • 26 for reserve component
  • Represents 3 of all vets seen in VA
  • VHA Office of Public Health and Environmental
    Hazards, February 14, 2006

16
Utilization of VA ServicesCharacteristics of
Patients
  • 87 male 13 female
  • Age 20-29 53 age 30-39 23
  • ARMY 66, USAF 13, USMC 11, USN 10
  • Active duty 49, Reserve Component 51
  • VHA Office of Public Health and Environmental
    Hazards, February 14, 2006

17
Clinical characteristics
18
Medical Diagnoses (N 144,424)
  • Musculoskeletal 40
  • Mental disorders 32
  • Digestive System 30
  • Ill Defined Symptoms 30
  • Nervous system 28
  • Respiratory 17
  • Injury/Poisoning 16
  • VHA Office of Public Health and Environmental
    Hazards, February 14, 2006

19
Spectrum of Post-Deployment Mental Disorders (N
46,571)
  • Disorder N
  • PTSD 20,638 44
  • Drug Abuse 17,768 38
  • Depression 14,317 31
  • Neurotic Disorders 11,481 25
  • Affective Psychosis 7,460 16
  • Alcohol Dependence 3,116 7
  • Acute Stress Reaction 1,327 3
  • VHA Office of Public Health and Environmental
    Hazards, February 14, 2006

20
Prevalence of Mental Disorders by War ZoneStrict
Diagnostic Criteria
21
Outcomes for Symptom Screening (Iraq)Liberal
Criteria
22
Health Risk Screening OutcomesDemobilization
Sites
  • Alcohol 33
  • Hostility 22.8
  • Suicide ideation/risk 1.1 - 4.1
  • Interpersonal Aggression/Domestic Violence 2.1
    - 2.2
  • Tobacco Use 50 (25 - 44 want to quit)

23
Health Risk BehaviorsVAPSHCS Clinic Sample (n
144)
24
Post-Deployment Readjustment ReactionsFunctional
Limitations
  • Unemployment
  • Financial deficits (lacking money management
    skills)
  • Homelessness
  • Phobias about driving
  • Reunion stress (over-controlling, detached,
    intimacy problems)
  • Marital conflict, parenting concerns and family
    reintegration problems (including divorce, DV,
    and infidelity)

25
Post-Deployment Readjustment ReactionsProminent
Arousal Symptoms
  • Disturbed sleep and dreaming
  • Easily startled
  • Irritability and anger
  • Hypervigilance (discomfort in crowds)

26
Post-Deployment Readjustment ReactionsCommon
Themes and Concerns
  • Addiction to CNN war coverage
  • Worry about friends still deployed overseas
  • Miss excitement of combat, urges to return
  • Worries about re-deployment

27
Traumatic Brain Injury
  • cognitive problems (e.g., impaired memory,
    attention, or executive function)
  • headaches
  • sensitivity to light or noise
  • dizziness or nausea
  • irritability, impulsivity, poor frustration
    tolerance
  • depression
  • insomnia
  • TBI can cause impaired or lost sensory function
    (e.g., eyesight), mobility, and ability to
    perform basic activities of daily living
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