Estimation of plasma Total plasma proteins

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Estimation of plasma Total plasma proteins

• Dr Laila zain

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Introduction

• Plasma contains more than 300 proteins
• Most of the proteins have specific function
  diagnostic value
• others have no function in the blood including
  enzymes and tumour markers

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Function of plasma proteins

• 1)Maintenance of colloidal osmotic pessure-
• 2)Transport function
• 3)Deffence reaction
• 4) coagulation function

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Clinical Importance

• Change in the concentration of plasma proteins
  can be measured and used in diagnoses and
  monitoring of many diseases. Organic diseases may
  result iftheir concentration is reduced.

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Methods Of Investigating Plasma Proteins

• 1)Chemical.2)Immunological 3)Electrophoresis

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Plasma Proteins and disease

• Factors affects plasma proteins concentration are
  1-Volume of distribution 2-Synthesis rates
  3-Catbolism 4-Excretion. Disease\ e.g Infections
  ,Immunological diseasis,Malignancy,Trauma.