BONES

1
CHAPTER 26

• BONES
• JOINTS
• SOFT TISSUE TUMORS

2
BONES, JOINTS,SOFT TISSUE TUMORS

• BONES
• JOINTS
• SOFT TISSUE TUMORS

3
BONES

• NORMAL
• PATHOLOGY

4
BONES - NORMAL

• MODELING/REMODELING
• GROWTH/DEVELOPMENT

5
PATHOLOGY

• DEVELOPMENTAL/ACQUIRED
• FRACTURES
• OSTEONECROSIS (AVASCULAR NECROSIS)
• INFECTIONS
• TUMORS
• MISC. TUMORS

6
GENETIC/ACQUIRED

• NUCLEAR PROTEIN/ DEFECTS
• HORMONE DEFECTS
• STRUCTURAL PROTEIN DEFECTS
• METABOLIC PATHWAY DEFECTS
• MACROMOLECULE DEGRADATION
• DECREASED BONE MASS
• OSTEOCLAST DYSFUNCTION
• ABNORMAL MINERAL HOMEOSTASIS

7
NUCLEAR PROTEINSTRANSCRIPTION FACTORS
8
HORMONE DEFECTS
9
STRUCTURAL PROTEINDEFECTS

• COLLAGEN DESEASE, TYPE 1 (OSTEOGENESIS
  IMPERFECTA)
• TYPES 2, 10, 11

10
DEGENERATION ofMACROMOLECULES

• MUCOPOLYSACCHARIDOSES

11
METABOLIC PATHWAYDEFECTS

• OSTEOPETROSIS

12
DECREASED BONE MASS

• OSTEOPOROSIS

13
OSTEOCLAST DYSFUNCTION

• PAGET DISEASE (Osteitis Deformans)

14
ABNORMAL MINERALHOMEOSTASIS

• RICKETS/OSTEOMALACIA
• HYPERPARATHYROIDISM
• RENAL OSTEODYSTROPHY

15
RICKETS/OSTEOMALACIA
16
HYPERPARATHYROIDISM
17
RENALOSTEODYSTROPHY
18
FRACTURES
19
OSTEONECROSIS(AVASCULAR NECROSIS)
20
OSTEOMYELITIS

• PYOGENIC
• TUBERCULOSIS
• SYPHILIS

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PYOGENIC OSTEOMYELITIS
22
TUBERCULOUSOSTEOMYELITIS
23
SKELETAL SYPHILIS
24
BONE TUMORS

• BONE FORMING TUMORS
• CARTILAGE FORMING TUMORS
• FIBROUS/FIBRO-OSSEOUS TUMORS
• MISC.

25
BONE FORMING TUMORS

• OSTEOMA
• OSTEOID OSTEOMA/OSTEOBLASTOMA
• OSTEOSARCOMA

26
OSTEOMA
27
OSTEOID OSTEOMA/OSTEOBLASTOMA
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OSTEOSARCOMA(OSTEOGENIC SARCOMA)
29
CARTILAGE-FORMINGTUMORS

• OSTEOCHONDROMA
• CHRONDROMA
• CHONDROBLASTOMA
• CHONDROMYXOID FIBROMA
• CHONDROSARCOMA

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OSTEOCHONDROMA
31
CHONDROMA
32
CHONDROBLASTOMA
33
CHONDROMYXOID FIBROMA
34
CHONDROSARCOMA
35
FIBROUS/FIBRO-OSSEOUSTUMORS

• FIBROUS CORTICAL DEFECT (NON-OSSIFYING FIBROMA)
• FIBROMA
• FIBROUS DYSPLASIA
• FIBROSARCOMA and MFH (MALIGNANT FIBROUS
  HISTIOCYTOMA)

36
FIBROUS CORTICAL DEFECT(NON-OSSIFYING FIBROMA)
37
FIBROMA
38
FIBROUS DYSPLASIA
39
FIBROSARCOMA and MFH
40
MISC. TUMORS

• EWING SARCOMA and PNET (PERIPHERAL
  NEURO-ECTODERMAL TUMOR)
• GIANT CELL TUMOR
• METASTATIC

41
EWING SARCOMA
42
PNET
43
GCT (GIANT CELL TUMOR)
44
METASTASES to BONE
45
JOINTS

• NORMAL
• PATHOLOGY

46
PATHOLOGY

• ARTHRITIS
• TUMORS

47
ARTHRITIS

• OSTEOARTHRITIS (DEGENERATIVE ARTHRITIS)
• RHEUMATOID ARTHRITIS (RA)
• JUVENILE RHEUMATOID ARTHRITIS
• SPONDYLOARTHROPATHIES
• INFECTIOUS
• GOUT
• PSEUDOGOUT

48
OSTEOARTHRITIS(DEGENERATIVE ARTHRITIS)
49
RHEUMATOIDARTHRITIS

• Morphology
• Joints
• Skin
• Blood Vessels
• Clinical Course

50
JUVENILE RHEUMATOID ARTHRITIS
51
SPONDYLOARTHROPATHIES

• ANKYLOSING SPONDYLOARTHRITIS
• REACTIVE ARTHRITIS
• PSORIATIC ARTHRITIS

52
GOUT(GOUTY ARTHRITIS)
53
PSEUDOGOUT(CALCIUM PYROPHOSPHATE)
54
TUMORS

• GANGLION (SYNOVIAL CYST)
• (PVN) PIGMENTED VILLONODULAR SYNOVITIS (GIANT
  CELL TUMORS OF TENDON SHEATH)

55
GANGLION
56
PVN(G.C.T. of TENDON SHEATH)
57
SOFT TISSUE TUMORS

• PATHOGENESIS
• FATTY
• FIBROUS
• FIBROHISTIOCYTIC
• SKELETAL MUSCLE
• SMOOTH MUSCLE
• SYNOVIAL SARCOMA

58
PATHOGENESIS GENERAL FEATURES
59
FATTY TUMORS

• LIPOMA
• LIPOSARCOMA

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FIBROUS

• BENIGN REACTIVE PSEUDOSARCOMATOUS LESIONS
• FIBROMATOSES
• FIBROSARCOMA

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PSEUDO-SARCOMATOUSCONDITIONS

• NODULAR FASCIITIS
• MYOSITIS OSSIFICANS

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NODULAR FASCIITIS
63
MYOSITIS OSSIFICANS
64
FIBROMATOSES

• SUPERFICIAL (Palmar, Plantar, Penile)
• DEEP (Desmoid Tumors)

65
FIBROSARCOMA
66
FIBROHISTIOCYTICTUMORS

• BFH (BENIGN FIBROUS HISTIOCYTOMA), aka,
  DERMATOFIBROMA
• MFH (MALIGNANT FIBROUS HISTIOCYTOMA)

67
SKELETAL MUSCLE TUMORS

• RHABDOMYOSARCOMA

68
SMOOTH MUSCLE TUMORS

• LEIOMYOMA
• LEIOMYOSARCOMA

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LEIOMYOMA
70
LEIOMYOSARCOMA
71
SYNOVIAL SARCOMA