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Role of CRP in Inflammatory Bowel Disease
Effective Marker for Diagnosis and
Treatment? Kareen Shebaclo, Carolyn Yates, Agnes
Usoro, Shana Talbot, Allan Angerio, PhD. School
of Nursing and Health Studies, Georgetown
University
Abstract
Levels of CRP in IBD
CRP in Conjunction with other Inflammatory Markers
CRP as a Biomarker for IBD
Inflammatory diseases, particularly Inflammatory
Bowel Disease, trigger high morbidity and
mortality rates in Americans every year.
Different types of IBD include Ulcerative
Colitis, affecting roughly 7.3 patients per
100,000 people per year, and Crohns Disease,
affecting 116 patients per 100,000 people per
year as well. Therefore deciphering means by
which clinicians can detect and diagnose these
diseases promote early detection critical for
disease mitigation. C - reactive protein, an
acute phase protein, has become a well-developed
marker used to screen and identify IBD in
patients. This project seeks to discover the link
between elevated C-reactive protein values in
relation to IBD, CRP expression, and the
stimulation of autoimmunity. Methods include
analyzing preceding research literature spanning
a decade of findings. Currently, CRP is the most
useful indicator of disease prognosis, disease
relapse, and treatment outcome. The usefulness of
CRP as a marker, however, differs between two
types of IBD, Crohns Disease and Ulcerative
Colitis. According to studies, success rates are
100 in CD and 60 in UC. Our research reveals
that in addition to being a diagnostic marker,
CRP may be a more powerful indicator if combined
with other factors such as erythrocyte
sedimentation Rate, platelet count, and
hemoglobin. Checking more than one marker in
addition to CRP may be the best way to diagnose
IBD early in hopes of thwarting the disease.
CRP Values in Ulcerative Colitis vs. Crohns
Disease
Production of CRP
Denotes most effective biomarkers in addition to
CRP
Conclusion
Crohns Disease
Ulcerative Colitis

• A TH-1 response
• TNF-a
• IL-12
• IFN-gamma
• IL-6

• A TH-2 response
• IL-4
• IL-5
• Il-13
• IL-6

• The highly sensitive evaluation of CRP using a
  lower limit for normal values is necessary to
  improve sensitivity of CRP to predict and
  diagnose active IBD accurately.
• Advantages of CRP testing differ from CD and UC
  since CRP levels are found at 100 in CD patients
  yet as low as 50 in UC patients.
• CRP as a laboratory marker is quite effective
  although not ideal. Currently, is the best tool
  to be used although better results appear when
  utilizing it in conjunction with other biomarkers
  clinical observations physical examinations.
• Most effective biomarkers in addition to CRP are
  platelet count and hemoglobin.
• CRP testing is not a replacement for clinical
  exams.

Different Roles of C- Reactive Protein
Study One 100 of patients with Crohns Disease
had increased CRP values, yet only 60 diagnosed
with Ulcerative Colitis had increased CRP
levels. Study Two Again, 100 of patients with
Crohns had elevated CRP values, but only 50 of
Ulcerative Colitis patients did.
Vermiere et al., 2004.
CRP Marker for Relapse
Inflammation