SURVEY OF BIOCHEMISTRY Lipids

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SURVEY OF BIOCHEMISTRYLipids Biological
Membranes
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CETL Course Survey(s)

• Course-Instructor Opinion Survey (CIOS)
• http//www.coursesurvey.gatech.edu
• Also on T-Square Home Page
• Pilot Survey
• Go to T-Square Announcements for link to survey
• Focus groups to learn more about student opinions
  
• Deadline August 3, 2008
• IRB Approval requested minimal risk

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PRS Update

• Scores on T-Square this weekend
• Next week
• Mon Fatty Acid Oxidation
• Wed and Fri Course Review via PRS
• Point Summary
• 75-100 of total points 10 PRS POINTS
• 50-74 of total points 5 PRS POINTS
• 1-49 of total points 1 PRS POINT
• 0 0 PRS POINTS

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Types of Lipids

• Fatty Acids
• Triacylglycerols
• Glycerophospholipids
• Sphingolipids
• Steroids
• Isoprenoids
• Eicosanoids

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Fatty Acids
Carboxylic acids with nonpolar hydrocarbon
chain Fatty acids can be saturated with Hs or
unsaturated with Hs
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Fatty Acids
Double bonds can be cis or trans - usually see
cis form
Cis form causesmolecule to kink
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Common Fatty Acids
Know C12 - C20 names and structures!
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Triacylglycerols

• R1, R2 and R3 are fatty acid chains
• Most abundant!
• Energy reservoirs

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Glycerophospholipids

• R1 and R2 are fatty acid chains
• X functional group
• Abundant in bio membranes

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Classes of Glycerophospholipids
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Phospholipases
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Sphingolipids
Sphingolipids are also found in membranes.
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SphingolipidsSphingomyelin

• Compose 10-20 of plasma membrane

Head group couldalso be a phosphoethanolamine
group -O3P-CH2CH2NH3
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SphingolipidsCerebrosides

• Sugar head group and no phosphate

From Avantilipids.com
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SphingolipdsGangliosides

• Most complex, found in brain tissue

Be familiar with structure but do not memorize
for Final Exam
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SteroidsStructure of Cholesterol
Know this!
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Steroids
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Steroids
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Arachidonic Acid Breakdown
Involved in pain and fever, blood pressure, blood
coagulation, reproduction
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Micelles
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Lipid Bilayer and Glycophorin A
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Biological Membranes