Group members:

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Effects and cooperations of INF-? and IL-12
Group members ??? ??? ??? ??
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our mottos

• In unity there is strength.
• Nothing is impossible to a willing heart.

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Sources of the two cytokines
Have some effects on the production of INF-?
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• Interleukin-12 (IL-12) is capital cytokine in
  cell-mediated immunity adjustment. Its biological
  functions involve stimulating T cells and NK
  cells to secrete Interferon-?(IFN-?),inducing
  CD4 T cells differentiated into Th1 type cells .

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Effects of IL-12

• 1 proliferation and function of activated
  CTLs(???T????) and NK cells
• 2 production of the INF-?
• 3 promotes TH1 cell introductionsuppresses TH2
  cell function
• 4 promote cell-mediated immunity
• 5 promote the differentiation from TH0 to TH0 and
  secrete IL-2 and INF-?

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• In the early period of viral infection, IL-12
  plays a necessary role.

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Classification of the INF

• Interferon first divided into type ? and type ?,
  ? type was found in another two components,
  although their total interferon receptor
  components, but the immunogenicity of the two
  completely different, so will be further divided
  into type ? a and ß two types, the former had
  said leukocyte interferon, which has called
  fibroblast interferon. Type ? is to be designated
  as ?-type, so it is now divided into three
  categories namely, interferon a, ß, ?.

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• IFN-?, produced mainly by Th_1 cells, CD8 T
  cells and natural killer cells, plays a critical
  role in anti-virus, anti-tumor, and immune
  modulation. Its immune modulation includes
  activating macrophages, upregulating the
  expression of MHC class I and class II molecules,
  prompting the presentation of antigens, and
  inducing Th cell growth and differentiation. The
  level of IFN-? is an important index to the
  cellular immunity.

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Effects of INF-?

• 1 induction of class ?MHC on all somatic cells
• 2 induction of class ? MHC on APCs and somatic
  cells
• 3 activation of macrophages,neutrophils and NK
  cells
• 4 enhancing the activity of TH1 cells,but
  inhibits the production of TH2 cells
• 5 acting on activated B cells to induce
  inmunoglobulin class switching to IgG1-an isotype
• 6 synergistically enhance the cytotoxic effects
  of INF-a
• 7 INF-? can stimulate gens translate and express
  of the complements

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• IFN-? is a typical Th1-type cytokines, can
  inhibit the growth of tumor cell lines with
  macrophage-activating factor of the role, can
  trigger macrophages to kill tumor effect and
  enhance cytotoxic T lymphocyte (CTL) and NK cells
  the ability of anti-target cells and inhibit Th2
  cell proliferation

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the cooperation of INF-? and IL - 12
IL - 12
INF-?
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Plesent cooperation
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Expectations of IL-12

• Because IL-12 in anti-tumor immunity and
  anti-infection immune to the important role that
  people have great expectations for its clinical
  application in particular, IL-12 can be
  coordinated to promote IL-2 and CTL have shown
  that LAK cells (??????????), IL-12 and IL - 2
  MS(??????) is expected to constitute a more
  effective method of tumor immunotherapy.

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Clinical application of IL-12

• 1 treatment of allergic diseases

2 treatment of autoimmune diseases

3 treatment of bacterial infections, fungal
4 treatment of viral diseases 5 treatment of
tumor 6 anti-fibrosis 7 anti-parasitic infection
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IL-12
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IFN?????Clinical Application

• Low concentration IFN-?S repressive effects

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Cytokine therapy

• IFN-a/IFN-ßare used for virus infection.
• IFN-?is better
• than IFN-a/IFN-ß.

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• IFN-?that has distinct immunological
  regulation and anti-tumor function. Due to its
  enormous regulating function in immune system,
  IFN-?is a promising cytokin .

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THANK YOU
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Figure 2-39
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