Facts about Kineret and InjectionSite Reactions

1
Facts about Kineret and Injection-Site Reactions

• Definition of ISRs from Kineret clinical
  trials
• Any sign or symptom that occurs at the location
  where Kineret is injected. Examples include
  bruising, redness, swelling, and pain (burning or
  stinging)

• Facts about ISRs, documented during Kineret
  clinical trials
• 71 of patients experienced at least one ISR
  however, 95 were reported as mild or moderate
• Regardless of severity, only 7 of patients
  dropped out of clinical trials due to an ISR
• ISRs generally occurred within the first 4 weeks
  and subsequently decreased in frequency
• Patients who do not experience an ISR within 4
  weeks are highly unlikely to experience an ISR

Some Kineret patients reported burning or
stinging during or immediately after the
injection. This sensation is a by-product of the
Kineret solution and tends to diminish over time.
2
Managing Kineret Injection-Site Reactions

• Apply a cold pack to the injection site 23
  minutes before and immediately after injection

• Bruising at the injection site

• Itching at the injection site

• Apply a topical hydrocortisone cream

• Apply a cold pack to the injection site
  immediately after injection

• Swelling at the injection site

• Try different injection sites the abdomen may be
  best because of the low number of nerve endings
• Warm Kineret? solution to room temperature before
  injecting
• Apply a cold pack to the injection site 23
  minutes before and immediately after injection
• Allow the alcohol at the injection site to dry
  before injection the alcohol may cause stinging

• Pain during and/or after injection

• Thoroughly inform patients about ISRs prior to
  initiating treatment