UCLA

1

• SUGGESTED POSTER FORMAT UCLA FACULTY/VC MIXER
  EVENT 6/15/05
• The poster format is provided below as a
  guideline (provided by VC's attending the event)
  to help assess marketablilty of your invention.
  This format is not required (except size), but is
  highly recommended.
• POSTER SIZE easels are provided for poster sizes
  up to 3' X 4'
• Color Powerpoint slides (8-12) attached to
  poster board are acceptable.
• Invention Poster Board Categories (generally, 1
  or 2 slides per category)
• Invention Title
• Technology (or Program) Background 1-2
  paragraphs provide big-picture overview of the
  technology area
• Problem customer's need/pain what market
  "pain" (customer needs) exists?
• Markets size lead customers describe market
  opportunity
• Solution scientific details competitive
  advantage over current/anticipated solutions
• Results supporting data
• Stage of Technology designate  discovery,
  technical feasibility, integration, or prototype
• Inventors credentials / about the lab / contact
  information
• IP Status number of filings provisional filed
  converted foreign filings
• For this example, data and text were kept to a
  minimum. Separate and/or additional slides for
  each category would otherwise be the norm.
  Additional slide examples are available. Please
  contact, Bob Nidever, 310-794-0607 ,
  bnidever_at_resadmin.ucla.edu , for more
  information.

2
Robotic Scanning Device for Imaging and
Manipulating Biological Material
Background

• Atomic force and fluorescent microscopy have
  each increased the ability of
• researchers to image, monitor and manipulate
  sub-cellular material, e.g. DNA

Problem

• Real-time optical analysis of biological
  material is a powerful imaging technique,
• but is limited when the biological structures
  are below the resolution of light
• microscopy
• Molecular manipulation technology (e.g. atomic
  force microscopy) is
• revolutionary in scope, but is low-throughput
  and not robust for clinical
• applications

Markets

• Cancer in-vitro diagnostic is 3.5 billion,
• growing at 12-15 annually
• Genetic analysis instrument market is
• 1 billion in annual sales

3
Robotic Scanning Device for Imaging and
Manipulating Biological Material
Solution
Array-based, atomic-precision, scanning probe
technology

• Optical microscopy would locate specific
• fluorescent probes
• Atomic Force Microscopy would then image and
• cut the biological material at a specific
  location
• Highly parallel, scalable for high-throughput
• Enables analysis of material from single cells
• Virtually unlimited multiplex capability
• Quick path to commercialization fluorescent
  and
• multiplexed AFM already exist

4
Technological Status
Robotic Scanning Device for Imaging and
Manipulating Biological Material
Research
Development
Commercialization
Discovery
Technical
Integration
Prototype
Production
Feasibility
Robotic Scanning Device for Imaging and
Manipulating Biological Material
5
Inventors and Collaborators
Robotic Scanning Device for Imaging and
Manipulating Biological Material

• James K. Gimzewski, Department of Chemistry and
  Biochemistry
• Jason Reed, Department of Chemistry and
  Biochemistry

Intellectual Property

• Four Patent Disclosures