Blood Cells

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Blood Cells
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Basophils

• Basophils - 10 to 15 u diameter.Basophils
  constitute approximately 0.5 to 1.0 of
  leukocytes and are therefore more difficult to
  find in a routine blood smear. The nucleus
  consists of 2 to 3 lobes but is usually not as
  lobulated as neutrophils. The cytoplasm is full
  of dark purple specific granules. Basophils are
  also phagocytic, but function largely like mast
  cells, (i.e. their granules contain histamine and
  heparin which play an important role in
  initiation of the acute inflammatory response).

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Eosinophils

• Eosinophils-- 10 to 15 um constitute 2.0 to 4.0
  of leukocytes. These cells usually contain a
  bilobate (two lobes) nucleus and a cytoplasm full
  of brightly stained eosinophilic (orange-red)
  specific granules. Eosinophils function
  specifically as phagocytes to destroy larvae of
  parasites that have invaded tissues i.e. in
  trichinosis, schistosomiasis, and appear to play
  a role in allergic responses. Other functions of
  eosinophils include phagocytosis of antigen
  antibody complexes.

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Neutrophils

• Neutrophils are leukocytes 10 to 15 u
  diameter.These cells constitute 70 of
  leukocytes and usually have 2 to 5 nuclear lobes
  connected by fine filaments of chromatin.
  Neutrophils are the most numerous of all
  leukocytes, therefore, easiest to identify.
•  

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Lymphocyte

• Lymphocytes - 9 to 14 um dia.Lymphocytes
  constitute 20 25 of agranulocytes and may be
  small, medium or large in size. The nucleus is
  rounded or oval, and usually the same size as an
  erythrocyte. The chromatin is densely packed with
  no apparent nucleoli. The cytoplasm is scanty and
  stains pale blue. Lymphocytes are composed of two
  types
• T lymphocytes B lymphocytes

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Monocytes

• Monocytes - 12 to 20 um diameter monocytes
  comprise 3 8 of agranulocytes. This large cell
  has a lightly stained nucleus that often appears
  horseshoe or kidney shaped. The chromatin appears
  lacy and nucleoli are usually not apparent. The
  nucleus looks a bit like a "brain." The abundant
  cytoplasm stains and quite often contains
  vacuoles (small, clear areas). These areas help
  to distinguish monocytes from large lymphocytes.
  Monocytes migrate into connective tissue and
  become Macrophages.

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Capillary as seen in the transmission electron
microscope (TEM)
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