Is There a Latent State of HIV Infection

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Is There a Latent State of HIV Infection?

• By Alice Cioara

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• HIV
• Instigates AIDS
• May work in conjunction with cofactors
• ex. Mycoplasma penetrans

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• HIV
• binds to surface receptor CD4 antigen of
• T lymphocytes and marcophages
• activate/delete T cells like a superantigen

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• HIV
• located
• In vivo tests show HIV expressed in T cells
• Some T cells contain dormant or suppressed HIV
  genomes while resting become infected
• Not all infected cells contain viral latency
• ex. Varicella-coaster virus

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• After initial infection with HIV
• followed by a rush of viraemia
• person may/may not have symptoms
• After HIV-1 infection
• viral DNA in form of a nucleoprotein complex
• complex needs to be moved to nucleus
• function to insert in genome

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• HIV
• at all stages of infection
• macrophages and lymphoid tissue actively
  expressed
• Conclusion
• HIV infection not latent during asymptomatic
  period.