Bone

1
Bone.a dynamic organ

• Functions
• Protection, shape, movement, sound
• Blood production in marrow
• Storage of minerals, growth factors, fat, metals
• 206 bones in mancalcium hydroxylapatite
  compositioncontaining osteoblasts and
  osteoclasts which modulate bone
• Diseases relate to minerals, D, hormones, drugs,
  weightlessness, etc.
• Are there stem cells in bone?

2
A bit of background

• . Albright, F. Butler, A. M. Hampton, A.
  O. Smith, P. 1937. Syndrome characterized by
  osteitis fibrosa disseminata, areas of
  pigmentation and endocrine dysfunction, with
  precocious puberty in females report of five
  cases. New Eng. J. Med. 216 727-746
• expanded clinical-pathologic scope
• aberrant Gs a coupling to adenyl cyclase
  resulting in cAMP overproduction
• Michienzi,S, Cherman, Holmbeck,
  Funari,Collins, Bianco, Robey 2007. GNAS
  transcripts in skeletal progenitors. Human Mol.
  Genet 16 1921-1930.