CELL BIOCHEMISTRY

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CELL BIOCHEMISTRY PROTEINS AND ENZYMES LECTURE 3
- PROTEINS - SECONDARY STRUCTURE
PROTEIN CONFORMATION SECONDARY STRUCTURE
b-PLEATED SHEET a-HELIX
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FORCES MAINTAINING 3D-STRUCTURE
1. HYDROGEN BONDS 2. HYDROPHOBIC INTERACTIONS 3.
Van der Waals FORCES 4. IONIC BONDS
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PAULING AND COREY RULES FOR MODEL BUILDING OF
SECONDARY STRUCTURES
1. Bond lengths and angles same as those
known for secondary amides 2. Every CO in a
peptide bond must be H-bonded to a H-N in another
peptide bond 3. All H-bonds must be approx.
linear 4. Every peptide bond must be planar
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PEPTIDE BOND TAUTOMERISM
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The planar peptide bond
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The a-helix
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b-PLEATED SHEET
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b-PLEATED SHEET
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HYDROGEN BONDS
Ice structure