Thrombocytopenia in Patients with Lupus Anticoagulant

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• Thrombocytopenia in Patients with Lupus
  Anticoagulant
• - in Correlation with Thromboembolism?
• R. Simanek 1, S. Panzer2, K. Lechner1, I.
  Pabinger1
• 1Division of Haematology and Haemostaseology,
  Department of Medicine I,
• 2Department of Blood Group Serology and
  Transfusion Medicine,
• Medical University of Vienna
• 12th Conference of the EHA, Vienna, June 7th 2007

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Aim

• To investigate, whether
• thrombocytopenia (TP) has an influence on
• the risk for thromboembolism (TE)
• in patients with persistent Lupus Antikoagulant
  (LA)

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Patientscharacteristics

• 124 patients with persistent LA
• 99 female, 25 male
• mean age 45 yrs., std.dev. 20 yrs.
• 86 patients had a history of TE
• 72 venous TE, 14 arterial TE
• 70 female, 16 male
• mean age 42 yrs., std.dev. 20 yrs.
• 14 patients fulfilled the criteria for Systemic
  Lupus Erythematodes (SLE), 11 of them had TE

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Results
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Results - Platelets lt 150,000/µl
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Results - Platelets lt 150,000/µl
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Results - Platelets lt 150,000/µl
OR 0.33 95 CI 0.12 0.94 p0.032
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Results - according to cut-off
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Results - according to cut-off
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Conclusion

• In our cohort TP was more common in those
  patients with LA who had not developed TE
• Due to its low specificity and sensitivity TP is
  not a reliable predictive parameter shown to have
  influence on TE in patients with LA

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Thank you...

• for your attention!

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In case of further questions...

• two more slides...

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Platelet antibodies in LA patients

• Subgroup analysis of 97 patients
• 65 patients had a history of TE
• Both groups had platelet antibodies, but the
  frequency was lower in patients with TE (plt0.01)
• There was no correlation between platelet
  antibodies and platelet count
• Schallmoser K., Lupus (2006)15, 507-14

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Platelet antibodies in LA patients
Optical densities by MAIPA against GP Ib/IX and
IIb/IIIa
Schallmoser K., Lupus (2006)15, 507-14