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Drosophila Polytene Chromosomes

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whether a Deletion Uncovers a Particular Gene. st/st. scarlet eye color. Del/st ... scarlet eye color. Deletion 'uncovers' scarlet. Pericentric Inversion (peri ... – PowerPoint PPT presentation

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Title: Drosophila Polytene Chromosomes


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Drosophila Polytene Chromosomes
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Euploidy Cells with complete SETS of
Chromosomes
Normal Ploidy
Haploid 1n
Diploid 2n
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Aneuploidy Loss or Gain of SINGLE chromosomes
Monosomy 2n -1
Trisomy 2n 1
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Chromosomal Rearrangements
DELETION
DUPLICATION
INVERSION
TRANSLOCATION
nonreciprocal
reciprocal
TRANSPOSTION
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Familial Retinoblastoma
RB Mutation in RB gene wildtype RB gene
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Detection of Large Deletions
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If Deletions Small
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Deletions can Uncover mutant genes
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Complementation Crossing Tests whether a
Deletion Uncovers a Particular Gene
X
Del/st Wildtype eye color
st/st scarlet eye color
Del/st scarlet eye color
st/st Wildtype eye color
Deletion uncovers scarlet
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Pericentric Inversion (peri surrounding)
centromere
Paracentric Inversion (para beside)
centromere
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Wildtype
Antennapedia
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Burkitts Lymphoma
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Metaphase I
Nonhomologous
chromosomes
randomly align on metaphase plate
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Alternate
Adjacent
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