Title: Drosophila Polytene Chromosomes
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2Drosophila Polytene Chromosomes
3Euploidy Cells with complete SETS of
Chromosomes
Normal Ploidy
Haploid 1n
Diploid 2n
4Aneuploidy Loss or Gain of SINGLE chromosomes
Monosomy 2n -1
Trisomy 2n 1
5Chromosomal Rearrangements
DELETION
DUPLICATION
INVERSION
TRANSLOCATION
nonreciprocal
reciprocal
TRANSPOSTION
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7Familial Retinoblastoma
RB Mutation in RB gene wildtype RB gene
8Detection of Large Deletions
9If Deletions Small
10Deletions can Uncover mutant genes
11Complementation Crossing Tests whether a
Deletion Uncovers a Particular Gene
X
Del/st Wildtype eye color
st/st scarlet eye color
Del/st scarlet eye color
st/st Wildtype eye color
Deletion uncovers scarlet
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14Pericentric Inversion (peri surrounding)
centromere
Paracentric Inversion (para beside)
centromere
15Wildtype
Antennapedia
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20Burkitts Lymphoma
21Metaphase I
Nonhomologous
chromosomes
randomly align on metaphase plate
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23Alternate
Adjacent