Recent Epidemiological Data and Implications for Management

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THE METABOLICSYNDROMEWeb Conference Paris,
December 2006

• Recent Epidemiological Data and Implications for
  Management

Sidney SMITH, MDDirector, Center for
Cardiovascular Science and MedicineUniversity
of North Carolina Chapell Hill (NC, USA)
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Metabolic Syndrome Increases CVD and All-cause
Mortality
1209 Finnish men
Lakka H, et al. JAMA 20022882709-2716.
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Patients with Coronary Heart Disease Have a High
Prevalence of Dysglycaemia
Euro Heart Survey
Glucose testing during acute admissions for
coronary heart disease Glucose testing done
electively in patients with coronary disease
Bartnik M, et al (Euro Heart Survey on diabetes).
Eur Heart J 2004251880-90.
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Abnormal Glucose Tolerance Predicts Mortalityin
Patients with Acute Myocardial Infarction
Bartnik M, et al. Eur Heart J 2004251990-7.
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Approximately Half of Patients with Acute
MyocardialInfarction Have Metabolic Syndrome
(RICO AMI France)

• Metabolic syndrome defined
• by NCEP ATP III criteria
• 633 patients with confirmed
• myocardial infarction

Zeller M, et al (RICO). Arch Intern Med.
20051651192-1198.
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Metabolic Syndrome Worsens Outcomes in Patients
with Acute Myocardial Infarction (RICO AMI
France)
Zeller M, et al (RICO). Arch Intern Med.
20051651192-1198.
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Diabetes and Metabolic Syndrome Worsen Long-term
Prognosis in Patients with Acute Myocardial
Infarction
G Levantesi G, et al. (GISSI-Prevenzione). J Am
Coll Cardiol 200546277-283.
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The Metabolic Syndrome Associates with a History
of Myocardial Infarction Greater than any of its
Individual Components
Ninomiya JK, et al. (NHANES III). Circulation
200410942-6.
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Whatever The Definition, The Metabolic Syndrome
Increases 1.5 to 2-fold The Risk of CV Events
Dekker JM, et al. (Hoorn study). Circulation
2005112666-673.