Chromatin

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Chromatin
Euchromatin
Heterochromatin
Facultative (X-chromosome)
Constitutive (Telomere, Centromere)
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(No Transcript)
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Chromosomes have Nucleosomes Beads on a String
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Solenoid
Nucleosome
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Histone (H1) for the Higher-order Structure
H1
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Chromosome
Scaffold
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Transcription Factors Protect 5S sRNA Genes from
Repression
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Transcription Activators Facilitate
Recruitment of General Transcription Factors
(GTFs)
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Tissue-specific Nucleosome Positioning
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Histone Deacetylases Favor Transcription Repressio
n
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Histone Deacetylases (HDAC) (Repression) versus
Acetyltransferases (HAT) (Activation)
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ATP-dependent Chromatin Remodeling
Swi/Snf Alter the structure of
nucleosome Iswi Move the nucleosome On DNA
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Chromatin ImmunoPrecipitation (CHIP) Assay