P1252428697Wuzfe - PowerPoint PPT Presentation

Title: P1252428697Wuzfe


1
European Voice Conference Chemicals and
consumers a question of confidence  Dr.
Matthias VeyInternational Fragrance
Association Tuesday December 4, 2007 Renaissance
Hotel Brussels, Belgium
2
Preparing for REACH
Common household fragrances may be harming
aquatic wildlife, study finds Stanford New
Service October 2004
A Whiff of Danger Synthetic Musks May Encourage
Toxic Bioaccumulation  Environmental Health
Pespectives January 2005
Environment group raises stink over perfumes
Agence France Presse 10 February 2005
Valentine perfume 'can make you sick' The
Guardian 11 February 2005
Study on Air Fresheners - BEUC Hits Back BEUC
Press Release February 2005
Greenpeace Study Critical of Some Fragrances
Womens Wear Daily 14 February 2005
Phthalates and Artificial Musks in Perfumes
RI-A R 2005/011 TNO-Report Greenpeace
January 2005
MY TOXIC VALENTINE GREENPEACE FINSD SUSPECT
CHEMICALS IN PERFUMES
3
Growth of the Scare Industry

• Excessive public campaigns
• Lead to increasing consumer mistrust.
• Result even in loss of materials that have been
  declared safe by numerous scientific institutions
  like DEP (Diethyl phthalate), sacrificed by the
  industry due to pressure by the misinformed
  consumer, scared by non-differentiating
  phthalate campaigns
• Become worse by advances in analytical chemistry
  (Relevance of finding 0.000000000001 of a
  material in blood, mothers milk or the
  environment?).
• May result in regulatory activities that tend to
  be based on hazard identification instead of risk
  assessments - potentially leading to unnecessary
  constraints danger of misusing the
  precautionary principle

Toxic bathroom
Toxic Valentine
Air fresheners cause a stink
4
Where is this leading to ?
5
Synthetic versus NaturalA twisted debate

• Chemo phobia fuelled by certain interest groups
  leads to strange consumer expectations
• Natural is generally regarded safe chemically
  derived (synthetic) as unsafe
• Naturals are per se neither more safe or less
  safe than synthetic materials a number of very
  potent toxins are naturally derived (think about
  the fugu in Japan) one of the strongest
  fragrance sensitizers is a natural extract

6
Vanilla Flower
Many chemicals used in modern perfumery were
developed between 1850 and 1910. Many
chemicals (so called aroma chemicals are
derived from the study of natural products. One
example is vanillin
Naturals
Fresh Vanilla pods
Synthetics
Dried Vanilla pods
7
Role of (Aroma) Chemicals
RECONSTITUTION
ORIGINALITY
Lily of the Valley
SUBSTITUTION
ECOLOGY
Musk deer, an endangered species
8
Synthetic versus NaturalA twisted debate

• If our industry wanted to provide fragrances only
  consisting of natural materials (like e.g. rose
  oil), they would be prohibitive for most of the
  consumers due to the price but would they be
  more safe?
• Basis for a decisions about the safety of an
  ingredient (synthetic as well as natural) is a
  sufficient set of data that allows a safety
  (risk) assessment

9
Who cares about fragrance safety!?

• Industry self-discipline versus regulation?
• to ensure the safe use of fragrance ingredients /
  fragrance compounds
• Stakeholders involved Sensitive points
• Regulators, Media, Adequate Science
• NGOs, Dermatologists Compliance - Control
• Consumers, Distributors Sufficient independence
• more
• The fragrance industry has a research program in
  place since more than 40 years and maintains a
  global regulatory system with the objective of
  protecting consumer health and the environment
  since 1973
• IFRA Self-regulation is fast, global and
  independent!

10
REXPAN Independent Panel of Experts
Hachiro Tagami, MD Tohoku Univ. School of
Medicine, Sendai, Japan
Jon M. Hanifin, MD Oregon Health Sciences
Univ. I. Glenn Sipes, PhD. (Chair) University of
Arizona Donald V. Belsito, M.D.Univ. of
Missouri David R. Bickers, MD Columbia
University, NY Adrianne E. Rogers, MD Boston
Univ. School of Medicine

• Prof. Magnus BruzeMalmo University Hospital,
  Sweden
• Prof. Peter CalowRoskilde University, Denmark
• Prof. Dr. Helmut A. Greim
• Neuherberg Institut für Toxikologie
• Munich, Germany
• Jean-Hilaire Saurat, MD
• Universitaire de Geneve, Switzerland

11
Fragrance Industry Safety Program

• Build on two pillars
• RIFM Research Institute for Fragrance
  Materials
• RIFM and its Expert Panel REXPAN are responsible
  for safety testing and risk assessmentwww.rifm.or
  g
• IFRA International Fragrance Association
• IFRA is responsible for the risk
  managementvia the IFRA Code of Practice and
  Standards for safe use of fragrance ingredients
• www.ifraorg.org

12
Perfumers dispose of approximately 2000
ingredients both natural and synthetic, with
which to create fragrances.
13
Complexity of the fragrance
The formula used in the manufacturing plant
First level
Full composition
Natural
Synthetic
Natural
Base
Natural
Natural
Synthetic
Natural
100 to 800 ingredients
Synthetic
Synthetic
Synthetic
Synthetic
Base
Natural
Base
Synthetic
The formula used for the risk assessment,
labelling, etc
14
DOWNSTREAM USE OF FRAGRANCE SUBSTANCES
USE REACH PRE-REGISTER REGISTER CHEMICAL SAFETY REPORT If gt 10 t/y per Legal Entity CHEMICAL SAFETY REPORT If gt 10 t/y per Legal Entity CHEMICAL SAFETY REPORT If gt 10 t/y per Legal Entity CHEMICAL SAFETY REPORT If gt 10 t/y per Legal Entity
USE REACH PRE-REGISTER REGISTER SUBSTANCE SAFETY ASSESSMENT .. and If . SUBSTANCE CLASSIFIES AS HAZARDOUS then ALSO Exposure Assessments for .. and If . SUBSTANCE CLASSIFIES AS HAZARDOUS then ALSO Exposure Assessments for .. and If . SUBSTANCE CLASSIFIES AS HAZARDOUS then ALSO Exposure Assessments for
USE REACH PRE-REGISTER REGISTER SUBSTANCE SAFETY ASSESSMENT CONSUMERS WORKERS ENVIRONEMT
COSMETICS (Dir. 76/768/EEC) always always NO, except YES for indirect exposure via environment YES, for ALL production compounding formulation YES, for ALL production compounding formulation FINAL FATE
NON-COSMETICS Household cleaners Airfresheners Articles, e.g. candles always always always always always always always always YES, for ALL direct indirect exposures YES, for ALL production compounding formulation YES, for ALL production compounding formulation FINAL FATE
FLAVORS For Food For Oral Care ( cosmetics) NO always NO always NO YES, as for Cosmetics NO YES, as for Cosmetics NO YES, as for Cosmetics
15
Globally Harmonised System

• The basis for setting classification and
  labelling has been harmonised to follow the UN
  GHS criteria
• The GHS system is made up of building blocks and
  allows countries / regions to pick and chose
  local systems with different regulatory basis
  will result ?
• Different hazard information for workers in
  different regions of the world
• Some countries (e.g. Japan) consider a risk based
  approach for consumer product labelling under the
  roof of the GHS, others do not ?
• Different hazard information / warning
  statements on the same consumer product in
  different regions of the world

Globally Harmonised System ?
16
Thank you very much for your attention
Avenue des Arts 6, B 1210 Bruxelles, Phone 32
2 214 2062, Email mvey_at_ifraorg.org
17
Sensitisation to the Fragrance Mix I IVDK 2007
Basis Schnuch et al Contact Dermatitis, 50
65-76 (2004)
18
IFRA Standards Recognition

• IFRA Standards are the only globally
  acceptedrisk management system for fragrance
  ingredients and receive high reputation from
  customer and authority point of view.
• Since 1990 the Brazilian regulation recognizes
  the self-regulation of the industry by official
  adoption of the IFRA Standards
• IFRA Standards are about to be introduced in the
  European Cosmetics law (IFRA prohibited already
  included, IFRA restricted in the process).
• The ASEAN Cosmetics Directive foresees a
  requirement for proving IFRA compliance.