Bispecific antibodies can recognize and bind two different antigens separately, so it can connect immune cells, viral molecules, etc. to tumor cells, thereby enhancing the killing effect on target cells, and it can also combines different antigens on the same tumor cell to enhance its binding specificity, thereby reducing side effects such as off-target toxicity. This bifunctional recombinant antibody has a higher therapeutic effect as a drug for treating tumors than a monoclonal antibody. https://www.creative-biolabs.com/bsab/
Ordinary tumor therapeutic antibodies can only bind to a single antigen with a relatively low binding specificity is relatively low, which is prone to off-target effects. Bispecific antibodies (bsAbs) can recognize and bind two different antigens separately, so it can connect immune cells, viral molecules, etc. to tumor cells, thereby enhancing the killing effect on target cells, and it can also combine different antigens on the same tumor cell to enhance its binding specificity, thereby reducing side effects such as off-target toxicity.
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Minibody is composed of a pair of single-chain Fv fragments which are linked via CH3 domains, and Fvs with distinct specificity, which paired to the former part through heterodimerization process. https://www.creative-biolabs.com/bsab/minibody-generation-service.htm