Metabolism Interaction PowerPoint PPT Presentations

Metabolism: Transformations and Interactions Chapter 7

Pharmacokinetic drug interactions are dealt in this presentation.

¢ Drug interactions of Meglitinides (Repaglinide & Nateglinide) are dealt in this presentation. ¢ Repaglinide is metabolized by the CYP3A4 and CYP2C8 and hence it interacts with Gemfibrozil, Azole antifungals, Dabrafenib, Montelukast, Macrolide antibiotics and Rifampicin. ¢ Nateglinide is metabolized by CYP2C9 (70%) and CYP3A4 (30%) and it interacts with Amiodarone and Macrolide antibiotics. It also interacts with NSAIDs, MAOIs, Trandolapril, Non selective beta blockers Thiazide diuretics, Corticosteroids, Danazol, Sympathomimetics, Phenytoin and St.John’s wort.

Metabolism: Transformations and Interactions Chapter 7 * Figure 7.3: ATP (Adenosine Triphosphate). ATP is one of the body s high-energy molecules.

DPP 4 Inhibitors interact with CYP3A4 inducers, CYP3A4 inhibitors and P-Glycoproteins inhibitors.

Sulfonylureas may interact with Azole antifungals (Fluconazole), Fibrates (Gemfibrozil), Sulphonamides (Trimethoprim), Macrolide antibiotics (Erythromycin), Rifampin, Bosentan, Antacids, Alpha glucosidase inhibitors, Bile-acid binding resins (Colestyramine, colestipol, and colesevelam), ACE inhibitors, Allopurinol and Alcohol.

Alpha-glucosidase inhibitors interact with drugs such as Digoxin, Warfarin, Sulfonylureas, Neomycin, Guar gum, Pancreatin, Amylase, Activated charcoal, Antimuscarinics, Paracetamol and Nifedipine.

Is the patient taking any herbal supplements? Does the herbal have efficacy for ... literature analysis (Fugh-Berman and Ernst, Herbal Drug 'Interactions and ...

Clinical Pharmacology of Boceprevir: Metabolism, Excretion, and Drug-Drug Interactions C Kasserra, E Hughes, M Treitel, S Gupta, and E O'Mara

Metabolism & Enzymes

Cell Energetics ... Metabolism

Metabolism ... Metabolism

metabolism you must know the key role of atp in energy coupling that enzymes work by lowering the energy of activation the catalytic cycle of an enzyme that ...

Metabolism Regulation of food intake food intake is motivated behavior depends on the interplay of complex processes in addition to the need for nutritients, many ...

Metabolism II Nearly all of the energy needed by the human body is provided by the oxidation of carbohydrates and lipids. Whereas carbohydrates provide a readily ...

METABOLISM Thyroid Gland is located in front of the trachea. It produces hormones: Thyroxine (T4) Triiodothyronine (T3) T4 and T3 regulate body metabolism and

An Introduction to Metabolism Is the totality of an organism s chemical reactions Arises from interactions between molecules An organism s metabolism transforms ...

Title: Microbial Metabolism Author: str0807 Last modified by: tiptap Created Date: 9/14/1999 6:21:26 PM Document presentation format: On-screen Show (4:3)

Metabolism Thermoregulation Hypothalamic thermostat monitors the blood temperature receives signals from peripheral thermoreceptors in the skin.

Lipid Metabolism

Species Interactions Section 4-2 Pages 92-93 Species Interactions Species within a community develop close interactions, known as symbiosis. Sym means together ...

Carbohydrate metabolism Any biochemistry textbook may work, e.g. Lippincott s Illustrated Reviews, Biochemistry, 3rd ed, Chapters 7-8,10-14 Roskoski, Biochemistry ...

Introduction to Metabolism

These enzymes metabolize drugs only because the drugs resemble the natural compound ... SSRI antidepressants) Drug Metabolism - Reduction Azo-reduction: Nitro ...

XENOBIOTIC METABOLISM ... Most importance enzyme in xenobiotic metabolism ... Activity of xenobiotic metabolizing enzymes can be vary between individual ...

Title: Metabolism - Diet & Nutrition Lecture PowerPoint Author: Tami Port Keywords: nutrition lecture powerpoint, nutrition and diet lecture ppt, metabolism lecture ...

Energy and Metabolism Chapter 6 Flow of Energy Energy: the capacity to do work -kinetic energy: the energy of motion -potential energy: stored energy Energy can take ...

These compounds are the products of secondary metabolism, which is the ... Many secondary compounds are brightly colored pigments like anthocyanin that ...

Protein-protein Interactions Suiseki(1/3) DNA replication The Immune system The E2F transcription factor The talin/viniculin/actin system is a system for the ...

Protein Interaction Networks Thanks to Mehmet Koyuturk

Interactions Within Ecosystems http://www.kidsgeo.com/images/ecosystem.jpg

Thiazolidinediones interact with Abiraterone, Pixantrone, Azole Antifungals, Fibrates, Teriflunomide, Dabrafenib and Rifampin. Pioglitazone also interacts with Calcium channel blockers (Nifedipine, Amlodipine), Cobicistat, Piperaquine, Ifosfamide, Tolvaptan, Midazolam, Tipranavir/Ritonavir, Macrolide antibiotics, Sulphonamides, Amiodarone, Topiramate, Oral contraceptives, Atorvastatin, Danazol and Trandolapril.

Metabolism Chapter 19 The Action of Leptin Leptin crosses the BBB To affect NTs released by neurons in the arcuate nucleus Influences other hypothalamic nuclei Which ...

metabolism glucose is the principle substrate used to form atp glycolysis occurs in cytoplasm anaerobic highlights of glycoylysis two atp converted to adp four adp ...

Energy, Enzymes, and Metabolism

Chapter 5: Microbial Metabolism

Metabolism of Lipoproteins Hyperlipoproteinemia MODERATE RISK SCORE 1 -

Metabolism Totality of an organism s chemical processes Catabolic pathways (release energy) Breakdown Respiration Anabolic pathway Build up Photosynthesis ...

chapter 6 an introduction to metabolism

Lipid soluble compounds reabsorbed (renal tubules) ... Metabolism then proceeds in apparent first order fashion. ... Intermediate blends among other ethnic groups ...

METABOLISM OF LIPIDS ... bond between fatty acid and other molecules can be hydrolysed using lipases enzyme Phosphoacylglycerols membrane component ...

AMDA and ASCP summarised top 10 danferous drug interactions involving Warfarin, ACE inhibitors, Digoxin or Theophylline with other drugs

Energy and Metabolism Chapter 8 Energy Energy Energy Metabolism All the chemical reactions carried out by the cell Metabolism Catabolic reactions: Break down large ...

Protein-protein interactions (PPIs) are established when protein molecules physically contact with each other through hydrogen or hydrophobic bonds, Van der Waals forces, ionic forces, or even covalent bonds.

Ground Rules for Metabolism Starr/Taggart s Biology: The Unity and Diversity of Life, 9e Chapter 6

Protein-Protein Interaction Network Gautam Chaurasia 08.07.04 Overview Introduction. Three Different Models: Structure of the protein-protein interaction network.

Herbal / Drug Interactions. Gary W. Elmer, R.Ph.,Ph.D. ... ShopKo 0.26 0.05. Shurfine 0.17 0.29. YourLife 0.28 0.19. Nature's Balance 0.03 0.01 ...

Briefly explain biosynthesis of cell constituents (requires energy) ...

Entero-hepatic circulation. Identifying significant interactions ... Examples of drugs eliminated by hepatic metabolism. Carbamazepine. Corticosteroids. Cyclosporin ...

Principles of metabolism regulation Molecular mechanisms of hormonal signal transduction

Metabolism CE421/521 Lecture Notes Sept. 12, 2006 Biodegradation Processes cometabolism, mineralization, and biodegradation biodegradation: b_____ of ...

DISORDER OF CARBOHYDRATE METABOLISM Ph.D., MD, Assistant Professor Hanna Saturska molecular formula C12H22O11 Major index which describes metabolism of carbohydrates ...

Nalbuphine ,fentanyl &,tramadol. Interactions. Naloxon(Narcan) ... decreases effect of tramadol (Systemic ,Spinal & Epidural) 100 times as potent as morphine. ...

Diabetic patients take Insulin and/or other oral hypoglycemic and antihyperglycemic drugs to control their blood sugar levels. Along with antidiabetic medicines they may take drugs such as OTC medicines, prescription medicines, etc.to treat other illnesses which may interact with them. Drug interactions of Insulin with other drugs like Fluoroquinolones, Betablockers, Aspirin, Thiazolidinediones, Antipsychotics, Androgens, Antimalarials and Orlistat are dealt in this presentation. The interactions of Insulin with Complementary and alternative medicines (CAM) such as Bitter melon, Ginkgo, Ginseng, Gymnema, Licorice and Fenugreek with smoking and with alcohol are also dealt in this presentation.

... family of enzymes Metabolizes a broad range of structurally diverse endogenous and exogenous compounds Structurally related family ... Taxol (cancer drug ...

Regulation of Metabolism Rationale for Regulation Biological Efficiency Flexibility: adaptaton to dietary changes Need for biosynthetic products Control of pre ...