Lactamase PowerPoint PPT Presentations

Powerful irreversible inhibitor of b-lactamases - suicide substrate ... Exists as a zwitterion and is soluble in water. Poorly absorbed through the gut wall ...

Title: Title of presentation Author: David Martin Livermore Description: Office 2000 build by www.mediasterling.com Last modified by: PMcCoy Created Date

The PDB is a resource which compiles essential information about many proteins. ... We'll be investigating -lactamase. Type PC1 into the search box. ...

b-Lactamase Inhibitors Clavulanic acid (Beecham 1976)(from Streptomyces clavuligerus) Weak, unimportant antibacterial activity Powerful irreversible inhibitor of b ...

Modest activity against Staphylococcus aureus Gram-negative bacteria Escherichia coli, Klebsiella pneumoniae, Proteus spp. Haemophilus influenzae, Neisseria spp.

We'll be investigating -lactamase. Type PC1 into the search box. ... Each group will investigate the following portions of the enzyme. Residues 31-100 ...

... 33% non-outbreak Few epidemic strains ... v rare Class D non-metallo-b-lactamases Important in Acinetobacter spp. ESBL Detection: ...

B ta-lactamases spectre tendu (BLSE) Int r t port aux CTX-M Olivier Vidon Clarisse Bourdin Mars 2005 Historique Fin de la 2 me guerre mondiale ...

ESBL (Enterobacteriaceae med resistensmekanismen extended spectrum beta-lactamase) anm lningar enligt smittskyddslagen 070201-070430 Rapporterade fall av ESBL 070201 ...

ESBL-producing Enterobacteriaceae DiNubile MJ et al. Eur J Clin Microbiol Infect Dis 2005; 24: 443-9. P. aeruginosa resistance DiNubile MJ et al. Eur J Clin ...

How should cephalosporin and penicillin results be reported? ... Tra nh du ng cephalosporin the he 3, aztreonam, hay cefuroxime ...

In-patient cases initially in Telford Hospital. Later spread to Shrewsbury Hospital ... Shrewsbury and Telford NHS Trust. New hospital cases of ESBL from May ...

ALTERATIONS WHICH CHANGE MOLECULAR DIMENSIONS & FLEXIBILITY ... benzylpenicillin. methicillin. Change in relative activity (lactamase labile) (lactamase stable) ...

Plasmids Plasmid genes for antimicrobial resistance often control the formation of enzymes that inactivate the antimicrobial drugs such as -lactamases, ...

Effective against Gm ? rods, Gm , anaerobes; effective against most -lactamases ... Disease caused by Bacillus anthracis, a gram-positive spore-forming bacteria ...

Antibiotic. Chemical substance produced by one spp ... Soil samples, lactamase, antibiotic activity, OM, cell wall, peptidoglycan, ...

... (extended-spectrum beta-lactamase) which is an enzyme that inactivates beta-lactam antibiotics such as the penicillins and cephalasporins Klebsiella ...

... genes -lactamase can destroy penicillin and other -lactam antibiotics Kanamycin interferes with Ribosomes Plasmids can be cut with restriction enzymes ...

Ampicillin resistance. Green Fluorescent Protein. Aequorea victoria jellyfish gene ... GFP. Cell wall. Beta lactamase (ampicillin resistance) ...

Penicillin binding proteins Penicillinase/beta lactamase. Autolysins Polymyxin B ... Non heat resistant. usually equipment. ultra-violet light. surfaces (e.g ...

Not themselves mobile, but excise and integrate cassettes that are ... Cassettes for b-lactamases, aminoglycoside resistance, chloramphenicol ...

QUICKLY REPLACE LIDS FLIP PLATES UPSIDE DOWN STACK AND TAPE LABEL WITH YOUR GROUP NAME PLACE IN INCUBATOR pGLO plasmid bla (beta-lactamase) - On all time - Makes ...

... effect of two drugs when used together (e. g. clavulinic acid and amoxicillin) ... Ampicillin and amoxicillin. Penicillins -lactamase inhibitors ...

Loma Linda University Children's Hospital. New trends, aminoglycoside toxicity ... Gram negative bacilli ( GNB) resistant to extended spectrum beta lactamases ...

12 August 2003. AmpC b-Lactamases & their detection. David Livermore ... c. 40,000; alkaline pI. Hydrolytic activity. 1st gen cephs rapid. 2/3 ceph cephs slow ...

After dialysis and treatment with oxygen, the enzyme's activity ... Lactamase is an enzyme that conveys resistance to -lactam antibiotics such as penicillins. ...

... significant side effects including hearing loss and seizures, and are typically ... Best examples are b-lactamases ... A molecular weight under 500 daltons ...

The chemical shift is dependant on the secondary structure, and ... Human carbonic anhydrase. Human thioredoxin red. III-glc. Interleukin 1a. Metallo-lactamase ...

... lactamases (ESBLs) and associated cephalosporin resistance are well established ... plain clavulanic acid and a cephalosporin disc are used, NO increase in ...

ceph S' ESBL producers. Prospective study of K. pneumoniae ... 2 Baxter & Lambert JAC 1997, 39, 838. MICs (mg/L) for E. cloacae. with metallo-b-lactamases ...

Beta-lactamase de type TEM-1. Constitutive, p riplasmique. Facile mettre en vidence ... 4.5 MDa ' Asiatique ' 3.05 MDA ' Toronto ' 2.9 MDa ' Rio ' 4.0 MDa ' ...

Deletion of the three underlined nucleotides (UAU) in the ... Which of the following enzymes is a target of the antibiotic erythromycin? A. beta-lactamase ...

Marketreportsonchina.com presents a report on “Investigation Report on China Piperacillin Sodium and Tazobactam Sodium Market [2010-2019]”. http://www.marketreportsonchina.com/life-sciences-market-research-reports-16505/investigation-china-piperacillin-tazobactam-sodium.html Tazobactam sodium can prevent piperacillin from the β-lactamase hydrolysis of some drug-resistant bacteria so as to maintain piperacillins antimicrobial activity or even expand its spectrum.

Marketreportsonchina.com presents a report on “Investigation Report on China Piperacillin Sodium and Tazobactam Sodium Market [2010-2019]”. http://www.marketreportsonchina.com/life-sciences-market-research-reports-16505/investigation-china-piperacillin-tazobactam-sodium.html Tazobactam sodium can prevent piperacillin from the β-lactamase hydrolysis of some drug-resistant bacteria so as to maintain piperacillins antimicrobial activity or even expand its spectrum.

Patrick An Introduction to Medicinal Chemistry 3/e Chapter 16 ANTIBACTERIAL AGENTS Part 3: Other lactams Newer b-Lactam Antibiotics Thienamycin (Merck 1976)(from ...

If you or someone you know has ever had a bacterial infection, you may have heard of Amclav Drops. This medication combines amoxicillin and clavulanic acid and is commonly prescribed for various types of bacterial infections. In this article, we'll examine what Amclav Drops are, how they work, and when they should be used.

... aminoglycoside 3rd ceph.) in Klebsiella pneumoniae in Europe (EARSS) 2005 Risk factors Control of ESBL outbreaks Enzymatic modification Enzymatic ...

-LACTAM ANTIBIOTICS THIENAMYCIN MONOBACTAMS -LACTAM INHIBITORS 1. Thienamycin Isolated from Streptomyces cattleya Potent and wide range of activity vs Gram +ve ...

Nosocomial infections are estimated to double the mortality and morbidity risks ... sodium content therefore can be safely used in patients on salt restricted diets ...

Chapter 8 Antibiotics Section 1. Lactam Antibiotics(2) Wei-Min Chen, Prof. Department of Medicinal Chemistry, JNU Topics in This Class Cephalosporins Non-typical ...

Structures less biased to library stereochemistry parameters ... Richard Bonnet. John Irwin. Sandri Soelaiman. Ruth Brenk. Binqing Wei. Alan Graves. Federica Morandi ...

Beta-lactam antibiotics - Cephalosporins Targets - PBP s Activity - Cidal - growing organisms (like the penicillins) Principles of action - Affinity for PBP s

Lecture 7a numbers commercialised

Antibiotics 102: Reading and Interpreting CLSI Antimicrobial Susceptibility Performance Documents Dave Warshauer, PhD, D(ABMM) Deputy Director, Communicable Diseases

Detection and Reporting of Beta-lactam Resistance in Enterobacteriaceae ... Adapted from Livermore and Woodford, Trends in Microbiol, 2006. The Gram Negative Cell Wall ...

M.D., M.Sc.(Canada), FIMSA, Senior Consultant Physician & Cardio-Metabolic Specialist Purpose of : To discuss the unique mechanism of action of daptomycin.

The isolate is resistant to imipenem (IPM 10) ceftazidime (CAZ 10) ... (CTX 5), cefotetan (CTT 30), Augmentin (AMC 60), and susceptible to aztreonam (ATM 30) ...

Beta-Lactam Antibiotics Clinically Important -Lactam Antibiotics Medicinal Chemistry Presentation David McLeod Southern Methodist University Cephalosporins Unlike ...

Altered antibiotic target/Overproduction of target. Reduced ... Inherent features of the bacterial species which prevent antibiotic action. Usually expressed ...

... (Vantin,) Cefteram Ceftibuten (Cedax) Ceftiofur Ceftiolene Ceftizoxime (Cefizox) Ceftriaxone (Rocephin) Classification of Cephalosporin 4.

TRATAMIENTO DE INFECCIONES GRAVES POR G RMENES PRODUCTORES DE BLEE Carmen Blanco UCI del H.Son Dureta Las infecciones causadas por BGN productores de BLEE pueden ser ...

NAG. NAG. NAM. NAM. NAM. NAG. NAG. NAM. NAM. NAM. NAG. NAG. Bond formation. inhibited by. penicillin. Cross linking ...

Produced by large scale fermentation (1944) ... Bicyclic system increases b-lactam ring strain. Not much variation in structure is possible ...

Swab E. coli ATCC 25922 onto plate to create lawn Place imipenem disk in center. ... Look for growth of E. coli around test isolate streak - indicates ...

Most modified chemically from original compounds found in nature, some isolated ... catalog/ProductDetail.do?N4=A1593|SIAL&N5=SEARCH_CONCAT_PNO|BRAND_KEY&F=SPE C ...

... Polar carboxylic acid group is masked by the ester Ester is metabolised in the body by esterases to give the free drug ... Stereochemistry at ... action involves ...