Lactamase PowerPoint PPT Presentations

Powerful irreversible inhibitor of b-lactamases - suicide substrate ... Exists as a zwitterion and is soluble in water. Poorly absorbed through the gut wall ...

Title: Title of presentation Author: David Martin Livermore Description: Office 2000 build by www.mediasterling.com Last modified by: PMcCoy Created Date

b-Lactamase Inhibitors Clavulanic acid (Beecham 1976)(from Streptomyces clavuligerus) Weak, unimportant antibacterial activity Powerful irreversible inhibitor of b ...

Modest activity against Staphylococcus aureus Gram-negative bacteria Escherichia coli, Klebsiella pneumoniae, Proteus spp. Haemophilus influenzae, Neisseria spp.

The PDB is a resource which compiles essential information about many proteins. ... We'll be investigating -lactamase. Type PC1 into the search box. ...

... 33% non-outbreak Few epidemic strains ... v rare Class D non-metallo-b-lactamases Important in Acinetobacter spp. ESBL Detection: ...

ESBL (Enterobacteriaceae med resistensmekanismen extended spectrum beta-lactamase) anm lningar enligt smittskyddslagen 070201-070430 Rapporterade fall av ESBL 070201 ...

B ta-lactamases spectre tendu (BLSE) Int r t port aux CTX-M Olivier Vidon Clarisse Bourdin Mars 2005 Historique Fin de la 2 me guerre mondiale ...

ESBL-producing Enterobacteriaceae DiNubile MJ et al. Eur J Clin Microbiol Infect Dis 2005; 24: 443-9. P. aeruginosa resistance DiNubile MJ et al. Eur J Clin ...

We'll be investigating -lactamase. Type PC1 into the search box. ... Each group will investigate the following portions of the enzyme. Residues 31-100 ...

How should cephalosporin and penicillin results be reported? ... Tra nh du ng cephalosporin the he 3, aztreonam, hay cefuroxime ...

In-patient cases initially in Telford Hospital. Later spread to Shrewsbury Hospital ... Shrewsbury and Telford NHS Trust. New hospital cases of ESBL from May ...

ALTERATIONS WHICH CHANGE MOLECULAR DIMENSIONS & FLEXIBILITY ... benzylpenicillin. methicillin. Change in relative activity (lactamase labile) (lactamase stable) ...

Effective against Gm ? rods, Gm , anaerobes; effective against most -lactamases ... Disease caused by Bacillus anthracis, a gram-positive spore-forming bacteria ...

Plasmids Plasmid genes for antimicrobial resistance often control the formation of enzymes that inactivate the antimicrobial drugs such as -lactamases, ...

... (extended-spectrum beta-lactamase) which is an enzyme that inactivates beta-lactam antibiotics such as the penicillins and cephalasporins Klebsiella ...

... genes -lactamase can destroy penicillin and other -lactam antibiotics Kanamycin interferes with Ribosomes Plasmids can be cut with restriction enzymes ...

Antibiotic. Chemical substance produced by one spp ... Soil samples, lactamase, antibiotic activity, OM, cell wall, peptidoglycan, ...

QUICKLY REPLACE LIDS FLIP PLATES UPSIDE DOWN STACK AND TAPE LABEL WITH YOUR GROUP NAME PLACE IN INCUBATOR pGLO plasmid bla (beta-lactamase) - On all time - Makes ...

Penicillin binding proteins Penicillinase/beta lactamase. Autolysins Polymyxin B ... Non heat resistant. usually equipment. ultra-violet light. surfaces (e.g ...

Ampicillin resistance. Green Fluorescent Protein. Aequorea victoria jellyfish gene ... GFP. Cell wall. Beta lactamase (ampicillin resistance) ...

Not themselves mobile, but excise and integrate cassettes that are ... Cassettes for b-lactamases, aminoglycoside resistance, chloramphenicol ...

12 August 2003. AmpC b-Lactamases & their detection. David Livermore ... c. 40,000; alkaline pI. Hydrolytic activity. 1st gen cephs rapid. 2/3 ceph cephs slow ...

... effect of two drugs when used together (e. g. clavulinic acid and amoxicillin) ... Ampicillin and amoxicillin. Penicillins -lactamase inhibitors ...

After dialysis and treatment with oxygen, the enzyme's activity ... Lactamase is an enzyme that conveys resistance to -lactam antibiotics such as penicillins. ...

Loma Linda University Children's Hospital. New trends, aminoglycoside toxicity ... Gram negative bacilli ( GNB) resistant to extended spectrum beta lactamases ...

... significant side effects including hearing loss and seizures, and are typically ... Best examples are b-lactamases ... A molecular weight under 500 daltons ...

Beta-lactamase de type TEM-1. Constitutive, p riplasmique. Facile mettre en vidence ... 4.5 MDa ' Asiatique ' 3.05 MDA ' Toronto ' 2.9 MDa ' Rio ' 4.0 MDa ' ...

The chemical shift is dependant on the secondary structure, and ... Human carbonic anhydrase. Human thioredoxin red. III-glc. Interleukin 1a. Metallo-lactamase ...

ceph S' ESBL producers. Prospective study of K. pneumoniae ... 2 Baxter & Lambert JAC 1997, 39, 838. MICs (mg/L) for E. cloacae. with metallo-b-lactamases ...

Marketreportsonchina.com presents a report on “Investigation Report on China Piperacillin Sodium and Tazobactam Sodium Market [2010-2019]”. http://www.marketreportsonchina.com/life-sciences-market-research-reports-16505/investigation-china-piperacillin-tazobactam-sodium.html Tazobactam sodium can prevent piperacillin from the β-lactamase hydrolysis of some drug-resistant bacteria so as to maintain piperacillins antimicrobial activity or even expand its spectrum.

Marketreportsonchina.com presents a report on “Investigation Report on China Piperacillin Sodium and Tazobactam Sodium Market [2010-2019]”. http://www.marketreportsonchina.com/life-sciences-market-research-reports-16505/investigation-china-piperacillin-tazobactam-sodium.html Tazobactam sodium can prevent piperacillin from the β-lactamase hydrolysis of some drug-resistant bacteria so as to maintain piperacillins antimicrobial activity or even expand its spectrum.

... lactamases (ESBLs) and associated cephalosporin resistance are well established ... plain clavulanic acid and a cephalosporin disc are used, NO increase in ...

Patrick An Introduction to Medicinal Chemistry 3/e Chapter 16 ANTIBACTERIAL AGENTS Part 3: Other lactams Newer b-Lactam Antibiotics Thienamycin (Merck 1976)(from ...

... aminoglycoside 3rd ceph.) in Klebsiella pneumoniae in Europe (EARSS) 2005 Risk factors Control of ESBL outbreaks Enzymatic modification Enzymatic ...

If you or someone you know has ever had a bacterial infection, you may have heard of Amclav Drops. This medication combines amoxicillin and clavulanic acid and is commonly prescribed for various types of bacterial infections. In this article, we'll examine what Amclav Drops are, how they work, and when they should be used.

Beta-lactam antibiotics - Cephalosporins Targets - PBP s Activity - Cidal - growing organisms (like the penicillins) Principles of action - Affinity for PBP s

M.D., M.Sc.(Canada), FIMSA, Senior Consultant Physician & Cardio-Metabolic Specialist Purpose of : To discuss the unique mechanism of action of daptomycin.

Lecture 7a numbers commercialised

Antibiotics 102: Reading and Interpreting CLSI Antimicrobial Susceptibility Performance Documents Dave Warshauer, PhD, D(ABMM) Deputy Director, Communicable Diseases

Chapter 8 Antibiotics Section 1. Lactam Antibiotics(2) Wei-Min Chen, Prof. Department of Medicinal Chemistry, JNU Topics in This Class Cephalosporins Non-typical ...

Detection and Reporting of Beta-lactam Resistance in Enterobacteriaceae ... Adapted from Livermore and Woodford, Trends in Microbiol, 2006. The Gram Negative Cell Wall ...

Beta-Lactam Antibiotics Clinically Important -Lactam Antibiotics Medicinal Chemistry Presentation David McLeod Southern Methodist University Cephalosporins Unlike ...

... (Vantin,) Cefteram Ceftibuten (Cedax) Ceftiofur Ceftiolene Ceftizoxime (Cefizox) Ceftriaxone (Rocephin) Classification of Cephalosporin 4.

Nosocomial infections are estimated to double the mortality and morbidity risks ... sodium content therefore can be safely used in patients on salt restricted diets ...

NAG. NAG. NAM. NAM. NAM. NAG. NAG. NAM. NAM. NAM. NAG. NAG. Bond formation. inhibited by. penicillin. Cross linking ...

TRATAMIENTO DE INFECCIONES GRAVES POR G RMENES PRODUCTORES DE BLEE Carmen Blanco UCI del H.Son Dureta Las infecciones causadas por BGN productores de BLEE pueden ser ...

Chemotherapy powerpoint for BPT Students

Swab E. coli ATCC 25922 onto plate to create lawn Place imipenem disk in center. ... Look for growth of E. coli around test isolate streak - indicates ...

MECHANISMS OF ACTION OF ANTIBIOTICS BACTERIOSTATIC AGENTS Sulfonamides Drugs inhibiting protein synthesis except aminoglycosides (macrolides, chloramphenicol ...

Most modified chemically from original compounds found in nature, some isolated ... catalog/ProductDetail.do?N4=A1593|SIAL&N5=SEARCH_CONCAT_PNO|BRAND_KEY&F=SPE C ...

The isolate is resistant to imipenem (IPM 10) ceftazidime (CAZ 10) ... (CTX 5), cefotetan (CTT 30), Augmentin (AMC 60), and susceptible to aztreonam (ATM 30) ...

ANTIMICROBIAL RESISTANCE Prof. Khalifa Sifaw Ghenghesh Each class of antimicrobial agent has a unique mode of action. Some antibiotics differ in their action on Gram ...

... Z Y A LacI lac Operon RNA Polymerase araC ara GFP Operon GFP Gene araC GFP Gene araC GFP Gene Effector (Arabinose) B A D araC B A D araC RNA Polymerase ...

... headache, dizziness & anxiety). Damage growing cartilage (arthropathy) Phototoxicity Contraindications Is preferably avoided in adolescents (under ...

Produced by large scale fermentation (1944) ... Bicyclic system increases b-lactam ring strain. Not much variation in structure is possible ...