Hepatotoxicity PowerPoint PPT Presentations

Acinus. Zones between 2 central veins. Zone 1. Closest to portal triad. High oxygen levels ... Oversupply of free fatty acids to liver. Decreased secretion of ...

Inability to break down tyrosine. Tyrosine build up in body, plasma, urine. 3 types (I, II, III) ... nodular cirrhosis post-mortem hallmark of the disease ...

Treatment of Active tuberculosis. S/S: dyspnea, fever, cough with sputum, ... GI upset, leucopenia or thrombocytopenia. RIF Hepatotoxicity. Prevalence: 10% to 15 ...

Drug and toxin Induced liver Disease hepatotoxicity from chemicals Drug Induced liver Disease Liver is the mayor detoxifying organ in the body. Liver is subjet to ...

Liver enzymes after starting ARVs. Outcome of interest ... that this may be elevating ALT through the development of fatty liver ...

'wasting' syndrome. hepatotoxicity. immunotoxicity. hematopoietic failure. repro toxicity ... Hazardous waste, old transformers. PCBs ...

LSU Clinical Pharmacology Drug Therapy of Gout Reginald D Sanders, MD Allopurinol - serious reactions fever, rash, toxic epidermal necrolysis hepatotoxicity, marrow ...

Hypertension May precipitate severe bradycardia/sinus arrest Hepatotoxicity- Coombs test (antiglobulin) necessary because autoantibodies are produced against Rh ...

Non-primate animal models 'wasting' syndrome. hepatotoxicity. immunotoxicity ... Human studies and primate models. chloracne. Ca risk ?peripheral neuropathy ...

Preoperative CT. Resectable mts. Initially not-resectable mts. Hepatotoxicity of CT ... Pre-operative chemotherapy in resectable CRC liver metastases. 34/40 ...

Keep pet cats indoors and feed commercially prepared cat food ... Stevens-Johnsons Syndrome. Lactic acidosis/hepatic steatosis. Hepatotoxicity. Hyperglycemia ...

Screening for androgen ... and other types of hepatotoxicities Not seen with the other replacement preparations Role of anti-estrogen ... Obesity Obesity and the ...

The incidence is around the general incidence of hepatotoxicity with HAART therapy, about 6%. Ritonavir appears to be higher, and indinavir can cause hyperbilirubinemia.

Acetaldehyde. Acetate. CO2 H2O. ROS. ADH. MEOS (Cyp2E1) ALDH. Direct Hepatotoxicity ... Cyp2E1 induction a liver injury (chronicity, zonality, other drugs, ...

Acetaminophen-induced hepatotoxicity is due to its reactive intermediate, ... metablites in urine, which constitutes 9% of a therapeutic dose of acetaminophen. ...

'Flag' for hepatotoxicity. Bromfenac NDA - Liver Signal ... Short-term use for pain should be 10 days ... Maximum daily dose limited to 150 mg/day ...

... because he has signs and symptoms of hepatotoxicity and peripheral neuropathy ... Peripheral neuropathy. Signs of muscle cramping/twitching and muscle weakness ...

In Vitro Toxicity is a scientific method of testing toxic chemical substances on cultured bacteria or mammalian cells. Drug toxicity is the major reason for withdrawal of drugs from the market which causes a company huge amount of financial costs and losses. Hepatotoxicity and cardiotoxicity are the most recurring drug toxicity. In Vitro toxicity involve assays of cultured bacteria or mammalian cells.

HIV, HBV and the Liver Rajesh T. Gandhi, M.D.

She was started anti-thyroid agent since half year ago. Present illness ... sclera : mild icteric. neck : supple, no LAP, no JVE. thyroid : impalpable ...

Strand Life Sciences 2006. 4. Our Approach ... Strand Life Sciences 2006. 14. Total adenine pool in the cytosol = ATPe ADPe AMPe= constant ...

13% females (N=108) versus 8% males (N=733) developed rash. Study 1182.52 (N=216) ... Female subjects on TPV/r have a higher frequency of rash than male counterparts ...

Multiendpoint Profiling of Hepatotoxicants in Vitro Thomas J. Flynn, Ph.D. FDA, Center for Food Safety and Applied Nutrition Disclaimer The views presented are those ...

Balancing HAART and hepatic safety. Paul Sax, MD. Brigham and Women's Hospital ... Liver toxicity is the most common severe adverse event in the HAART era ...

A phase I study on the combination of neoadjuvant radiotherapy plus pazopanib in patients with locally advanced soft tissue sarcoma of the extremities

Mechanisms of all the reactions of OTC Analgesics are dealt in easy way.

Colonoscopy: Confirmed Ischemic colitis. 10. Lotronex and ... Colonoscopy-patchy, friable, ischemic or hyperemic, edematous mucosa with erosions that later ...

Methoxyflurane Introduction It is first time introduced in USA in 1960 2,2 dichloro 1,1 difluoro-ethyl methyl ether ...

Griseofulvin binds microtubule proteins, inhibit cell wall synthesis. Terbinafine is an ergosterol ... Are we going to hit MRSA like situation in mycology? ...

Sarma GR, Immanuel C, Kailasam S, Narayana ASL, Venkatesan P. ... Non-Eskimo (284) 44. Eskimo (216) 95. Sunahara (2) Japanese (1808) 88.5. Ryukyuan (124) 85.5 ...

... and destroy the invaders or by antibodies that inactivate foreign Materials. e.g Contact dermatitis due to exposure to poison ivy Systemic erythematous in ...

This is a retrospective audit on the management of patients who were admitted ... adopted by the Royal College of Paediatrics and Child Health and the British ...

... use for general anaesthesia. Single agent or ... Indication included Anaesthesia and Analgesia (obstetrics/minor procedures) ... Anaesthesia versus Analgesia ...

Belladonna, henbane, mistletoe, St. John's wort, scopolia. Amantadine. Belladonna, henbane, pheasant's eye, scopolia. The Ugly. Dangerous Supplements Recommended ...

Safety and Effectiveness of Internal Analgesic Products ... Suppository. September 19, 2002 NDAC. 7. Risk/Benefit of OTC Internal Analgesic Drug Products ...

NSAID Corticosteroids Disease-modifying anti-rheumatic drugs (DMARDs) -- Hydroxychloroquine (Plaquenil ...

... 5 x ULN women CD4 250 11% CD4 250 1% men CD4 400 6 ... Relative risk 1.17 per year of ART 1.16 per year of PI therapy 0.94 per year of NNRTI therapy ...

Pharmacology &Therapeutics. Mechanisms of Drug Induced Liver Injury. The Ground Glass Phenomenon ... Pharmacology and Therapeutics. 112 (2006). 184-196. ...

... Support as well as the ACPE Criteria for Quality and ... Cohort study. 472 HIV patients followed for 8343 patient-months. HIV alone (n=126) HIV/HBV (n=72) ...

Ant-Infective Drugs Antibacterials Sulfa Drugs Urinary Anti-tuberculosis Antifungals Antivirals

Critical Analysis of the Risk/Benefit Ratio Related to the Use of Guidelines for ... In: Haslett C, Chilvers ER, Boon NA, Colledge NR, Hunter JAA, eds. ...

Assistant Professor of Neurology and Pediatrics. NYU ... Aphasia. Tiagabine Interactions. No effect on Phenytoin, CBZ. Probably no effect on Phenobarb ...

Tuberculosis is an infectious lung disease caused by bacteria that spreads through the air through coughing, sneezing, or spitting. In this presentation "Treatment of Tuberculsois (TB)" has been described including their causes, therapy, Principles, diagnosis, symptoms, management, etc. For more information, please contact us: 9779030507.

... who developed APAP-induced fulminant hepatic failure was analyzed retrospectively ... given), than other forms of fulminant liver disease, such as viral hepatitis ...

TREATMENT OF T.B. A special problem within the field of chemotherapy. TREATMENT OF T.B. Treatment is often complex and protracted. Host immune defenses are often ...

... sensitivity Empiric Therapy The antibiotic selected is one that can ... antibiotic to reach target site Augmentin,Unasyn ... on an empty stomach.

Title: PowerPoint Presentation Author: strand17 Last modified by: strand Created Date: 5/27/2002 6:29:10 AM Document presentation format: On-screen Show

Transporters involved in hepatic CL may determine systemic ... Gelled Collagen Plates. Rat Hepatocytes in Primary Culture. 0. 2. 4. 6. 8. 10. 12. 14. 16. 18 ...

Establish Causation, Molecular Mechanisms, Applications, etc ... Most patients with CNS side effects don't have high EFV levels. ...

DSaRM Advisory Committee. May 18, 2005. Active Surveillance for Drug Safety ... Funded mainly by unconditional grants from pharmaceuticals ...

Recognizing Drug-Induced Liver Injury (DILI) in Exposed Populations John R. Senior, M.D. Associate Director for Science Office of Pharmacoepidemiology and Statistical ...

analgesic, antipyretic with weak anti-inflammatory properties. APAP Question 2 ... Bezoar formation. Salicylate-induced pylorospasm. Gastric outlet obstruction ...

Marketing in US began March 97. Adv Cmt (12/11/96) 8-0 vote for AP ... Adv Cmt (3/26/99) 11-1 B R for concomitant use with insulin; 12-0 B R for ...

Central fat accumulation. Peripheral fat wasting. Risk factors. Female ... Intra-abdominal fat. Cholesterol. TG. Insulin resistance. PIs ... belly' ...

Glutathione stores depleted. NAPQI accumulates. Alcohol & other CYP450 inducers ... Chronic alcohol depletes glutathione. 7. What don't we know? ( Our knowledge gaps) ...