Drug Interactions Of Antidiabetics PowerPoint PPT Presentations

¢ Drug interactions of Meglitinides (Repaglinide & Nateglinide) are dealt in this presentation. ¢ Repaglinide is metabolized by the CYP3A4 and CYP2C8 and hence it interacts with Gemfibrozil, Azole antifungals, Dabrafenib, Montelukast, Macrolide antibiotics and Rifampicin. ¢ Nateglinide is metabolized by CYP2C9 (70%) and CYP3A4 (30%) and it interacts with Amiodarone and Macrolide antibiotics. It also interacts with NSAIDs, MAOIs, Trandolapril, Non selective beta blockers Thiazide diuretics, Corticosteroids, Danazol, Sympathomimetics, Phenytoin and St.John’s wort.

Sulfonylureas may interact with Azole antifungals (Fluconazole), Fibrates (Gemfibrozil), Sulphonamides (Trimethoprim), Macrolide antibiotics (Erythromycin), Rifampin, Bosentan, Antacids, Alpha glucosidase inhibitors, Bile-acid binding resins (Colestyramine, colestipol, and colesevelam), ACE inhibitors, Allopurinol and Alcohol.

DPP 4 Inhibitors interact with CYP3A4 inducers, CYP3A4 inhibitors and P-Glycoproteins inhibitors.

Alpha-glucosidase inhibitors interact with drugs such as Digoxin, Warfarin, Sulfonylureas, Neomycin, Guar gum, Pancreatin, Amylase, Activated charcoal, Antimuscarinics, Paracetamol and Nifedipine.

Drug interactions of Incretin mimetics (Exenatide) with other drugs like Warfarin, Digoxin, Paracetamol, Antibacterials, Thyroid hormones, Danazol and ACE inhibitors are dealt in this presentation. The interactions of Amylin analogue (Pramlintide) with other drugs such as Alpha glucosidase inhibitors, Danazol, ACE inhibitors, Thyroid hormones, Paracetamol and Antimuscarinics are also dealt in this presentation.

Diabetic patients take Insulin and/or other oral hypoglycemic and antihyperglycemic drugs to control their blood sugar levels. Along with antidiabetic medicines they may take drugs such as OTC medicines, prescription medicines, etc.to treat other illnesses which may interact with them. Drug interactions of Insulin with other drugs like Fluoroquinolones, Betablockers, Aspirin, Thiazolidinediones, Antipsychotics, Androgens, Antimalarials and Orlistat are dealt in this presentation. The interactions of Insulin with Complementary and alternative medicines (CAM) such as Bitter melon, Ginkgo, Ginseng, Gymnema, Licorice and Fenugreek with smoking and with alcohol are also dealt in this presentation.

Metformin interacts with Cationic drugs, Carbonic anhydrase inhibitors, Injection of iodinated contrast materials, phenprocoumon, dofetilide, rifampin, colesevelam, enalapril, trandolapril, guar gum and glycopyrrolate.

Safety of Herb - Drug combination treatments

Herb-drug interactions Charlotte Gyllenhaal, Ph.D. Department of Medicinal Chemistry and Pharmacognosy, Block Center for Integrative Cancer Treatment

Herb-drug interactions Charlotte Gyllenhaal, Ph.D.1,3 Gail Mahady, Ph.D.2 Departments of Medicinal Chemistry and Pharmacognosy,1 Pharmacy Practice2

Herb-drug interactions Charlotte Gyllenhaal, Ph.D. Department of Medicinal Chemistry and Pharmacognosy, Block Center for Integrative Cancer Treatment

Herb-drug interactions Charlotte Gyllenhaal, Ph.D. ... Saw palmetto lipid extract. Case report of intraoperative hemorrhage (w/o warfarin) ...

The Organic Chemistry of Drug Design and Drug Action Chapter 5 Enzyme Inhibition and Inactivation Enzyme Inhibition and Inactivation Categories of Enzyme Inhibitors ...

Case Report Female, age 76, hx of hypertension, osteoarthritis, gastropathy due to NSAIDs, atrial fibrillation, stroke: presents at ER with hematuria and bleeding gums.

1. FDA Interactions with Drug Advisory Committees. A Case Study on Diabetes ... intramural research programs. 4. Establishment Process ...

Thiazolidinediones interact with Abiraterone, Pixantrone, Azole Antifungals, Fibrates, Teriflunomide, Dabrafenib and Rifampin. Pioglitazone also interacts with Calcium channel blockers (Nifedipine, Amlodipine), Cobicistat, Piperaquine, Ifosfamide, Tolvaptan, Midazolam, Tipranavir/Ritonavir, Macrolide antibiotics, Sulphonamides, Amiodarone, Topiramate, Oral contraceptives, Atorvastatin, Danazol and Trandolapril.

High probability that absolute safety does not exist. Potential for causing unanticipated and unintended drug reactions and experience ... Polypharmacy ...

Drug Safety in Chronic Kidney Disease Primary Care Clinician Conference 4/26/14 Michael J Choi, MD Johns Hopkins University School of Medicine mchoi3@jhmi.edu

Title: Acute Renal Failure Author: Johns hopkins Last modified by: Jessica Joseph Created Date: 7/30/2002 12:40:54 AM Document presentation format

TRADITIONAL DRUGS AND HERBAL MEDICINES (PHYTOTHERAPY) Kuswinarti and Muchtan Sujatno Department of Pharmacology & Therapy Medical School , Padjadjaran ...

Title: PowerPoint Presentation Author: sheashaa Last modified by: Empodat Created Date: 1/1/1601 12:00:00 AM Document presentation format: On-screen Show (4:3)

Drug use in the elderly HOW TO PRESCRIBE APPROPRIATELY Know the actions, adverse effects, and toxicity profiles of the medications you prescribe.

Acts at GPCR in the liver to facilitate gluconeogenesis and mobilization of glycogen stores ... induce insulin secretion, decrease in gluconeogenesis ...

17. Medicines, Drugs - part 2. The Pharmaceutical. Industry ... Transfer to 'shake flasks' ,with food (Sugars) and nutrients (ammonium salts) ...

Thyroid hormones and antithyroid drugs Dept of Pharmacology Shi-Hong Zhang ( ) shzhang713@zju.edu.cn Thyroid hormones Hyperthyroidism Hypothyroidism cretinism ...

Chapter 13. Drug Design and Discovery Drug Discovery Clinical Trials Drug Discovery Drug Discovery Without a Lead Lead Discovery High-throughput Screens (HTS) Lead ...

Herbal pharmacology and Drug interaction of TCM Dr. Baisong Zhong M.D(China), Ph.D, L.Ac. WWW: Painandacupuncture.netfirms.com E-mail: Painandacupncture@yahoo.com

Adverse and toxic effects of drugs. Drug interactions (drug-drug) Food and drug interactions ... At least two animal species (one rodent and one non-rodent) ...

Types of OTC Drugs Internal analgesics Salicylates Ibuprofen-like Acetaminophen Therapeutic considerations Analgesic actions Anti-inflammatory effects Antipyretic ...

Drug Discovery and Development Process of Anti-diabetic Plants Dr. Basavaraj K. Nanjwade M. Pharm., Ph. D Professor of Pharmaceutics KLE University College of Pharmacy

ES cells are derived from early mouse embryos and have the capacity to ... Mice resulting from transgenic and gene knockout experiments develop, are ...

Hanlon JT, et al. J Am Geriatr Soc 2001;49:200-9. Total Drug Therapy Cost Control ... Lindblad C, Hanlon J et al. Clin Ther 2006 (in press) ...

Metabolic Activation and Idiosycratic Drug Toxicity: By Avoiding Structural Alerts, Do We Mitigate Risks? Amit S. Kalgutkar, Ph.D. Pfizer Global Research and Development

Used for the palliative treatment of advanced breast cancer. ANDROGENS. Drug interactions: ... the treatment of advanced prostate cancer. Include: Goserelin ...

Combination of drugs with similar effect. Low therapeutic index ... Peroral antidiabetics. Peroral anticoagulants. Heart glykosides. Antiepileptics. Antimanics ...

Non-steroidal Anti-inflammatory Drugs Dr.B.V.Venkataraman Professor in Pharmacology International Medical School Faculti Perubatan, New BEL Rd Bangalore - 560054

Right time drugs at developped disease loose effectivity ... Right patient is the one who needs the drug and we know his risk profile. Polypharmacy ...

Drugs with several types of therapeutic effects fit under several classifications (Aspirin) ... Poppy Plant Paregoric, Antidiarrheal, (Opium) Morphine, Analgesic, ...

Identify uses and varying actions of these drugs. ... with type II diabetes if diet and exercise can't control blood glucose levels. ...

... are required to achieve the desired effect Untoward Effect A side effect of a drug that is harmful to the patient PHARMACOKINETICS Study of the metabolism ...

A common cause for drug recalls ... Normally not observed until phase III or post launch ... Trazodone (antidepressant) Hepatitis. Trimethoprim (antibacterial) ...

lung fibrosis at silicosis and collagenoses ... Cutaneous lupus erythematous. Photosensitivity induced by drugs. Hyperthyroidism ...

Hawthorn Actions: Cardio tonic, cardio protective, antioxidant, hypotensive antiarrhytmic Medicinal Uses: traditional drug to treat heart problems, hypertension ...

Briefly review information that you have already had in your paramedic programs. The purpose of this program is not to teach new concepts of pharmacology ...

Paramedic Interfacility Transfer PHARMACOLOGY New Hampshire Department of Safety, Division of Fire Standards and Training & Emergency Medical Service

Medication Presentation Torry A. Hansen Glyburide Generic name: Glyburide Brand name: Micronase Other brand names: DiaBeta, Glynase Classifications: Therapeutic ...

antidiabetic agents ji sl va

is a product (other than tobacco) that is intended to supplement the ... Unpredictable: ACE inhibitors such as captopril, enalapril, lisinopril, and Monopril ...

Based on 2 open-label trials, ... In other words, what percent of new users of each class (reading down), ... Probably closest to capturing true new diabetics ...

has anorectic effect. low risk of hypoglycemia. don't lead to weight gain ... central anorectic effec. 2. Orlistat. inhibitor of intestine lipase. less ...

Medicinal Herbs Class Poster Presentations

Review the reasons why people are using herbal/ alternative medicines. ... serotonin reuptake inhibitors (SSRIs; Prozac , Zoloft , Celexa , and Lexapro ...

... students in Medical University, how to improve the seven-year program teaching, ... To improve the students' medical English level, faculty members direct ...

(PRICE LOWERED) Seriously the Easiest Way to Learn Pharmacology

Human Immunology and Application in Medicine Immunology Self-defense Pathogens: Bacteria Virus Parasites (1 ...

R.A.Howland, M.J.Mycek: Lippincott's Illustrated Reviews: Pharmacology,3rd ed. ... The inner (zona reticularis) - adrenal androgens (e.g., dehydroepiandrosterone) ...